From the Research
The histopathology of Grover's disease is characterized by acantholytic dyskeratosis with suprabasal cleft, a basket weave epidermic pattern with hyperkeratosis, and a perivascular lymphocytic infiltration in the upper dermis, as seen in the study by 1. The histopathological features of Grover's disease can vary, but the most common patterns include Darier-like, Hailey-Hailey-like, pemphigus-like, and spongiotic, as described in the study by 2.
- Acantholysis is a hallmark of the disease, resulting from the loss of cell-to-cell adhesion due to defects in desmosomal proteins.
- Dyskeratotic keratinocytes are typically present, and there may be a mild to moderate lymphohistiocytic infiltrate in the upper dermis.
- Immunofluorescence studies are typically negative, which helps differentiate it from autoimmune blistering diseases, as noted in the study by 3. The study by 4 provides a review of subtypes of Grover's disease, focusing on management options, but does not specifically address histopathology. The study by 5 discusses the seasonal variation of transient acantholytic dyskeratosis, but does not provide detailed information on histopathology. Overall, the histopathological features of Grover's disease are crucial for diagnosis and differentiation from other vesiculobullous and acantholytic disorders.