Cellulitis: This is a common bacterial skin infection that can cause swelling, redness, and blisters on the lower extremities. The presence of blisters, especially if they are filled with a cloudy or purulent fluid, strongly suggests a bacterial infection like cellulitis.

Deep Vein Thrombosis (DVT): While DVT typically presents with swelling and warmth of the affected limb, it can sometimes cause blistering due to the increased pressure and fluid buildup. The swelling associated with DVT is usually unilateral.
Contact Dermatitis: An allergic reaction or irritant contact dermatitis can cause swelling and blistering on the lower extremities, especially if the individual has come into contact with an allergen or irritant.
Eczema (Dyshidrotic Eczema): This condition is characterized by small, itchy blisters on the hands or feet, which can become swollen and inflamed.

Necrotizing Fasciitis: A severe and potentially life-threatening infection that can cause swelling, blisters, and necrosis of the skin and underlying tissues. Early recognition and treatment are crucial to prevent significant morbidity and mortality.
Compartment Syndrome: Increased pressure within a muscle compartment can cause swelling, pain, and blistering due to compromised blood flow. This condition requires immediate medical attention to prevent permanent damage.

Bullous Pemphigoid: An autoimmune disease that causes blistering of the skin, which can sometimes be accompanied by swelling. It is more common in older adults.
Epidermolysis Bullosa: A group of genetic conditions that result in fragile skin and blisters, which can be exacerbated by minor trauma or friction, potentially leading to swelling.
Lymphedema: Chronic swelling of the limb due to impaired lymphatic drainage, which can sometimes lead to the formation of blisters, especially if there is associated skin infection or damage.