From the Guidelines
Latuda (lurasidone) can be used with tadalafil (Cialis), but caution is advised due to potential interactions that may affect blood pressure. When considering the use of these medications together, it's essential to weigh the benefits against the potential risks, particularly in patients with pre-existing cardiovascular conditions. The primary concern is the potential for additive hypotensive effects, as Latuda may cause orthostatic hypotension and tadalafil is a vasodilator that lowers blood pressure 1.
Key considerations when using Latuda with tadalafil include:
- Monitoring for symptoms of low blood pressure, such as dizziness, lightheadedness, or fainting
- Starting with lower doses of tadalafil, such as 5mg, to minimize potential interactions
- Informing healthcare providers about all medications, including over-the-counter drugs and supplements, to assess specific risk factors and monitor for adverse effects
It's also important to note that the 2023 AHA/ACC/ACCP/ASPC/NLA/PCNA guideline for the management of patients with chronic coronary disease highlights the importance of careful consideration when using phosphodiesterase type 5 inhibitors, such as tadalafil, in patients with cardiovascular conditions 1. However, this guideline does not specifically address the interaction between Latuda and tadalafil.
In clinical practice, the decision to use Latuda with tadalafil should be guided by the individual patient's needs and risk factors, with careful monitoring for potential adverse effects. The benefits of using Latuda and tadalafil together may outweigh the risks for some patients, but caution and close monitoring are essential to minimize potential interactions.
From the Research
Interaction between Latuda and Tadalafil
- There are no direct studies on the interaction between Latuda (lurasidone) and tadalafil (Cialis) in the provided evidence.
- However, the studies provide information on the pharmacology and drug interaction effects of phosphodiesterase 5 (PDE5) inhibitors, such as tadalafil, with other medications 2, 3, 4.
- Tadalafil is known to be a mild vasodilator and can cause decreases in blood pressure, but these effects are generally considered clinically insignificant when used with most antihypertensive agents 2, 4.
- The interaction between tadalafil and alpha-blockers, such as doxazosin and tamsulosin, has been studied, and precautions are necessary to avoid orthostatic hypotension 3, 5.
- There is no evidence to suggest that Latuda would interact with tadalafil in a way that would be significantly different from other medications, but caution should always be exercised when combining medications.
Potential Risks and Considerations
- Patients taking Latuda and tadalafil should be monitored for potential decreases in blood pressure and orthostatic hypotension 3, 5.
- The risk of hypotension may be increased in patients taking multiple medications that can cause vasodilation or decrease blood pressure 2, 4.
- Healthcare providers should carefully evaluate the potential benefits and risks of combining Latuda and tadalafil in individual patients.