From the Research
Rosuvastatin can cause lower leg swelling, although it is not a common side effect, and the mechanism is not fully understood, but it may be related to increased vascular permeability or changes in fluid balance, as suggested by a study published in 2023 1. The swelling, also known as peripheral edema, typically appears as puffiness in the ankles and lower legs. If you experience swelling while taking rosuvastatin, you should contact your healthcare provider rather than discontinuing the medication on your own. Some key points to consider:
- The study published in 2023 1 found that rosuvastatin administration can significantly reduce the incidence of post-thrombotic syndrome (PTS) and cause a difference in the size of the lower limbs within 3 months.
- Another study published in 2018 2 reported a case of drug-induced angioedema involving rosuvastatin, which resolved after discontinuation of the medication.
- A study published in 2010 3 reviewed the safety of rosuvastatin and found that it is associated with relatively low rates of severe myopathy, rhabdomyolysis, and renal failure, but may cause adverse effects related to the gastrointestinal tract and central nervous system.
- A case report published in 2020 4 described a patient who developed bilateral foot myopathy while taking rosuvastatin, which resolved after discontinuation of the medication. It's essential to continue monitoring your cholesterol levels and cardiovascular health while addressing any side effects. Your doctor might recommend elevating your legs, reducing salt intake, or wearing compression stockings to help manage the swelling. In some cases, they might adjust your dosage or switch you to a different statin.