From the Research
Tianeptine is a potentially addictive atypical antidepressant that should only be used under strict medical supervision due to its opioid-like effects and high abuse potential, as evidenced by recent studies 1, 2.
Overview of Tianeptine
Tianeptine is an atypical antidepressant medication that works differently from most other antidepressants. It's primarily used to treat major depressive disorder, anxiety, and sometimes asthma-related depression. Unlike traditional antidepressants that increase serotonin levels, tianeptine appears to modulate glutamate activity and affect opioid receptors in the brain.
Dosage and Administration
The typical dosage is 12.5 mg taken three times daily, though this may vary based on individual needs and medical guidance. However, it's crucial to note that the therapeutic dose can be exceeded, leading to severe consequences, including euphoria and withdrawal symptoms 3.
Side Effects and Abuse Potential
Side effects can include nausea, constipation, abdominal pain, headaches, and dizziness. The most significant concern with tianeptine is its abuse potential due to its opioid-like effects at high doses. Studies have shown that tianeptine can lead to dependence, tolerance, and overdose, especially when used without medical supervision 1, 2.
Regulation and Availability
Tianeptine is not FDA-approved in the United States, though it is prescribed in some European, Asian, and Latin American countries under brand names like Stablon and Coaxil. Its availability online and in retail stores without prescription has raised concerns about its misuse and the need for regulation.
Key Considerations
- Tianeptine has a relatively rapid onset of action compared to many antidepressants, with some patients reporting benefits within days rather than weeks.
- Withdrawal symptoms can be severe, and it may interact with other medications.
- Recent studies highlight the dangers of tianeptine and the urgent need to regulate its use 1, 2.
- The use of tianeptine should be approached with caution, and patients should be closely monitored for signs of abuse and dependence.