From the Research
Yes, a tianeptine overdose can cause electrocardiogram (EKG) changes, as evidenced by the most recent and highest quality study available 1. Tianeptine, an atypical antidepressant, has been associated with cardiac conduction abnormalities in overdose cases, including QT interval prolongation, QRS widening, and arrhythmias. These EKG changes occur because tianeptine affects cardiac ion channels at high doses, particularly sodium and potassium channels, which are crucial for normal heart electrical activity. The severity of EKG changes typically correlates with the amount ingested, with significant overdoses potentially causing more pronounced cardiac effects. Other cardiovascular manifestations of tianeptine overdose may include:
- Tachycardia
- Hypotension
- In severe cases, cardiac arrest Healthcare providers treating suspected tianeptine overdose should obtain baseline EKGs and monitor cardiac function, as these changes can indicate serious toxicity requiring immediate intervention. Treatment typically involves:
- Supportive care
- Cardiac monitoring
- Addressing specific arrhythmias if they develop, as reported in studies such as 2 and 3. It is essential to note that while some studies, like 4 and 5, provide valuable information on tianeptine's pharmacological profile and potential for abuse, the most critical consideration in the context of overdose is the potential for cardiac complications, as highlighted in the more recent study 1.