From the Research
Patients with Dravet Syndrome taking Epidiolex (cannabidiol) should be counseled about several important side effects, including somnolence, decreased appetite, diarrhea, fatigue, malaise, weakness, rash, insomnia, and infections, as well as the risk of liver injury and potential interactions with other medications, as reported in the most recent study 1. The most common side effects of Epidiolex include:
- Somnolence (sleepiness)
- Decreased appetite
- Diarrhea
- Fatigue
- Malaise
- Weakness
- Rash
- Insomnia
- Infections Liver injury is a serious concern, with elevated liver enzymes occurring in some patients, so regular liver function monitoring is necessary 2. Epidiolex may cause sedation, especially when combined with other central nervous system depressants like benzodiazepines or alcohol. Some patients experience significant weight loss due to decreased appetite. Hypersensitivity reactions, though rare, can occur. Patients may also experience suicidal thoughts or behaviors while taking Epidiolex. These side effects occur because cannabidiol affects multiple systems in the body, including the endocannabinoid system and liver metabolism. The medication interacts with several anti-seizure medications, particularly clobazam, potentially increasing side effects 3. It is essential to note that the side effect profile of Epidiolex may vary depending on the patient population and the specific study, as seen in the different studies 4, 5, 2, 3. However, the most recent and highest-quality study 1 provides the most reliable information on the side effects of Epidiolex in patients with Dravet Syndrome. Patients should be advised not to stop taking Epidiolex suddenly as this could worsen seizures, and they should inform all healthcare providers about this medication to avoid potential drug interactions.