From the Guidelines
Ashwagandha (Withania somnifera) should be used with caution due to its potential risks and interactions, particularly its sedative properties and ability to alter the safety profile of prescribed medications, as noted in a 2020 review published in the American Journal of Kidney Diseases 1. When considering the use of ashwagandha, it is essential to weigh its benefits against its potential risks. The benefits of ashwagandha include reducing stress and anxiety, improving sleep quality, enhancing cognitive function, and potentially supporting immune function. However, the risks associated with ashwagandha use include gastrointestinal discomfort, drowsiness, and potential liver issues with long-term use. Additionally, ashwagandha may lower blood sugar and blood pressure, which could be problematic for certain individuals.
Some key points to consider when using ashwagandha include:
- Typical dosages range from 300-600mg of root extract daily, with effects often becoming noticeable after 2-8 weeks of consistent use.
- Ashwagandha may enhance the effects of thyroid medications, sedatives, immunosuppressants, and diabetes medications, potentially requiring dosage adjustments.
- It could also interfere with medications metabolized by the liver, as many medications used in anesthesia are metabolized by the cytochrome P-450 (CYP450) pathway, and pharmacokinetic contributions of dietary supplements like ashwagandha may either attenuate or enhance the sedative properties of certain anesthetics 1.
- Pregnant or breastfeeding women should avoid ashwagandha, and it's advisable to discontinue use at least two weeks before scheduled surgeries due to its potential effects on blood glucose and blood pressure.
It is crucial to be aware of the potential interactions between ashwagandha and other substances, including medications and other dietary supplements. For example, ashwagandha may interact with sedatives, such as valerian root, and other substances that can potentiate γ-aminobutyric acid and the effects of barbiturates and benzodiazepines 1. Therefore, it is recommended to consult with a healthcare professional before using ashwagandha, especially if you are taking any medications or have any underlying medical conditions.
From the Research
Benefits of Ashwagandha
- Ashwagandha root extract has been found to be beneficial in reducing stress and anxiety in healthy adults 2.
- It has also been shown to improve sleep quality and mental alertness in the elderly population 3.
- Ashwagandha has been found to have a positive effect on the functioning of the endocrine system, including improving the secretory function of the thyroid gland, normalizing adrenal activity, and multidirectional improvement on functioning of the reproductive system 4.
- It has also been found to strengthen muscle activity and reduce total- and LDL- cholesterol 5.
Risks of Ashwagandha
- One study found that Ashwagandha was well-tolerated in healthy adults, with no adverse events reported 6.
- However, another study found that one volunteer experienced increased appetite, libido, and hallucinogenic effects with vertigo at a low dose of Ashwagandha 5.
- The safety and toxicity of Ashwagandha remain important issues, which may affect its potential use in specific patient groups 4.
Interactions of Ashwagandha
- Ashwagandha may interact with certain medications, such as blood thinners, and decrease their effectiveness 4.
- It may also interact with thyroid medications and decrease their effectiveness 4.
- However, more research is needed to fully understand the potential interactions of Ashwagandha with other medications.
Dosage and Safety
- The recommended dose of Ashwagandha root extract varies from 125 mg to 600 mg per day, depending on the specific health condition being treated 2, 3.
- Ashwagandha has been found to be safe and well-tolerated in healthy adults at doses up to 600 mg per day 6, 5.
- However, long-term studies and varying dosage ranges should be investigated in the future to fully understand the safety and efficacy of Ashwagandha 6.