From the FDA Drug Label
The FDA drug label does not answer the question.
From the Research
Taking Vyvanse with food, particularly a light meal containing some protein, can help reduce gastrointestinal irritation and alleviate stomach upset. Ensuring adequate hydration throughout the day by drinking plenty of water is also essential. Timing adjustments, such as taking the medication earlier in the day, can prevent sleep disruption while allowing digestive symptoms to subside before bedtime. Over-the-counter options like antacids (such as Tums), H2 blockers (like famotidine/Pepcid), or proton pump inhibitors (such as omeprazole/Prilosec) may provide relief for acid-related discomfort, though these should be discussed with a healthcare provider first 1.
Some key points to consider when managing stomach upset caused by Vyvanse include:
- Stomach upset often improves after the first few weeks of treatment as the body adjusts to the medication
- If symptoms persist or worsen, consulting the prescriber is crucial, as they might consider adjusting the dosage, switching to an extended-release formulation, or trying a different ADHD medication altogether
- Vyvanse can cause stomach upset because stimulants increase norepinephrine levels, which can affect gastrointestinal motility and reduce blood flow to digestive organs 2
- The most commonly exhibited side effects of LDX, the active ingredient in Vyvanse, were appetite suppression, weight loss, headache, and insomnia, but gastrointestinal side effects can also occur 1
It's essential to weigh the benefits of Vyvanse in managing ADHD symptoms against the potential gastrointestinal side effects and work closely with a healthcare provider to find the best approach for individual patients.