From the Research
Ashwagandha may potentially cause liver damage in some individuals, though this appears to be rare, and the most recent and highest quality study suggests that it is an emerging cause of herb-induced liver injury. Most people can take ashwagandha without experiencing liver problems, but there have been documented cases of liver injury associated with its use, as reported in a 2023 study published in Pharmaceuticals (Basel, Switzerland) 1. People with pre-existing liver conditions should be particularly cautious and consult with a healthcare provider before taking ashwagandha. The typical recommended dosage ranges from 300-600 mg daily of a root extract, with some studies using up to 1,000 mg daily without widespread reports of liver toxicity. However, the exact mechanism by which ashwagandha might cause liver damage isn't fully understood, and it may involve individual sensitivity, interaction with medications, or possibly contaminants in some supplements, as suggested by a 2023 study published in Hepatology communications 2.
Some key points to consider when taking ashwagandha include:
- Purchasing from reputable sources to minimize the risk of contamination
- Following dosage guidelines to reduce the risk of liver injury
- Considering periodic liver function tests if using ashwagandha long-term, especially for individuals with pre-existing liver conditions
- Being aware of the signs of liver problems, such as yellowing of the skin or eyes, dark urine, abdominal pain, or unusual fatigue, and seeking medical attention immediately if these symptoms occur, as reported in a 2024 study published in Cureus 3.
It is also important to note that ashwagandha-induced liver injury can present with cholestatic hepatitis and can lead to the syndrome of acute-on-chronic liver failure with high mortality in those with pre-existing liver disease, as reported in a 2023 study published in Hepatology communications 2. Therefore, it is crucial to approach the use of ashwagandha with caution and to prioritize liver health when considering its use, especially in light of the emerging evidence of its potential to cause liver damage, as reported in a 2023 study published in Pharmaceuticals (Basel, Switzerland) 1.