From the Research
Ashwagandha should be avoided by individuals with elevated liver enzymes or hepatitis, and it is recommended to stop taking this herb if you have liver issues due to its association with rare cases of liver injury. The herb contains compounds that require liver metabolism, which could potentially add stress to an already compromised liver. While ashwagandha is generally considered safe for most healthy adults, those with pre-existing liver conditions should exercise caution as the herb might worsen liver function or interfere with the liver's healing process 1. Additionally, ashwagandha may interact with medications used to treat liver conditions, potentially reducing their effectiveness or increasing side effects.
Some studies have reported cases of ashwagandha-induced liver injury, with symptoms such as jaundice, nausea, lethargy, pruritus, and abdominal discomfort 2, 1. The liver injury pattern is typically cholestatic or mixed, with severe jaundice and pruritus, but self-limited with liver tests normalizing in 1-5 months 2. However, one case of ashwagandha-related liver injury ended with liver transplantation 1.
It is essential to consult with a healthcare provider who can evaluate your specific situation and liver enzyme levels before considering any herbal supplement with liver issues 3, 4. They might recommend alternative approaches to address whatever symptoms you were hoping to treat with ashwagandha that won't put additional strain on your liver. Abnormal liver enzymes can be categorized based on the pattern and magnitude of aminotransferase elevation, and it is crucial to interpret these tests accurately to provide appropriate further workup, treatment, and referral 5.
In summary, the potential risks associated with ashwagandha use in individuals with elevated liver enzymes or hepatitis outweigh any potential benefits, and it is recommended to avoid ashwagandha in these cases. If you are already taking ashwagandha and have liver issues, it is recommended to stop taking the herb and consult with a healthcare provider.