From the Research
Full spectrum Cannabidiol (CBD) has been shown to be effective in reducing seizures in patients with treatment-resistant epilepsies, with a median percentage reduction of 46%-66% in seizure frequency, as demonstrated in a recent study published in 2023 1. The efficacy of CBD in seizure management has been consistently demonstrated across various studies, with a significant reduction in seizure frequency observed in patients with different types of epilepsy, including Lennox-Gastaut syndrome, Dravet syndrome, and tuberous sclerosis complex. Some key points to consider when using CBD for seizure management include:
- Typical therapeutic dosages range from 5-20 mg/kg/day, divided into two daily doses, though treatment should always be initiated and monitored by a healthcare provider.
- Full spectrum CBD contains multiple cannabinoids, including a small amount of THC (less than 0.3%), which may provide an "entourage effect" potentially enhancing its effectiveness compared to CBD isolate.
- CBD works by interacting with the endocannabinoid system and other neurological pathways, potentially reducing neuronal hyperexcitability that contributes to seizures.
- Side effects may include drowsiness, diarrhea, reduced appetite, and potential drug interactions, particularly with anti-seizure medications.
- Regular follow-up with a healthcare provider is essential to monitor effectiveness and adjust dosing as needed. It's worth noting that while the evidence is promising, more research is needed to fully understand the effects of CBD on seizure management, particularly in the long term, as highlighted in a study published in 2021 2. Additionally, a systematic review published in 2021 3 found that highly purified CBD can be effective in treating seizures associated with various epilepsy syndromes, including those beyond Dravet syndrome and Lennox-Gastaut syndrome. Overall, the current evidence suggests that full spectrum CBD may be a valuable treatment option for patients with treatment-resistant epilepsies, and its use should be considered under the guidance of a healthcare provider, with careful monitoring of efficacy and potential side effects.