From the Research
The treatment for a thin endometrial wall typically involves estrogen therapy to promote endometrial growth, with the most recent and highest quality study suggesting cell-based therapy as a promising alternative for endometrium regeneration 1. When considering treatment options, it's essential to prioritize morbidity, mortality, and quality of life as the primary outcomes.
- Estrogen therapy, such as oral estradiol (2-6 mg daily) or vaginal estradiol (tablets or cream) for 2-3 weeks, can effectively increase endometrial thickness, with a goal of achieving an endometrial thickness of at least 7-8 mm 2.
- Additional treatments may include low-dose aspirin (75-100 mg daily) to improve blood flow to the uterus, vitamin E supplements (600 mg daily), and pentoxifylline (400 mg twice daily) which can enhance endometrial receptivity 3.
- In some cases, vaginal sildenafil (25 mg four times daily for 4-10 days) may be prescribed to increase uterine blood flow, although its effectiveness is still debated 4.
- For women with Asherman's syndrome (intrauterine adhesions), hysteroscopic surgery to remove adhesions may be necessary before hormonal treatment.
- Lifestyle modifications, such as maintaining a healthy weight and reducing stress, may also support endometrial health. It's crucial to note that the effectiveness of treatment depends on various factors, including the duration of estrogen administration and the quality of embryos transferred 2.
- Cell-based therapy, including the use of stem cells, platelet-rich plasma, and growth factors, has emerged as a promising alternative for endometrium regeneration, with potential benefits in improving endometrial thickness and reproductive outcomes 1.