From the Guidelines
Fish oil supplements, containing omega-3 fatty acids, have been shown to significantly reduce the risk of heart disease and all-cause mortality, with recommended intakes ranging from 0.5 to 1.8 grams per day of EPA and DHA. The benefits of fish oil supplements are well-established, with large-scale epidemiologic studies and randomized controlled trials demonstrating their effectiveness in reducing cardiovascular disease risk [ 1 ]. The American Heart Association recommends consuming at least two servings of fish per week, particularly fatty fish, to reduce the risk of heart disease [ 1 ]. For those who cannot get enough omega-3 fatty acids from their diet, supplements may be recommended, with a dose of 1 gram per day for risk reduction [ 1 ].
Some key benefits of fish oil supplements include:
- Reducing plasma triglycerides and improving insulin sensitivity [ 1 ]
- Lowering the risk of heart disease and all-cause mortality [ 1 ]
- Having beneficial effects on platelet aggregation and thrombogenicity [ 1 ]
- Being beneficial in subjects with diabetes, particularly in reducing plasma triglyceride levels [ 1 ]
However, it is essential to note that fish oil supplements may increase plasma LDL cholesterol, so monitoring is required [ 1 ]. Additionally, the effects of fish oil supplements on glucose metabolism are not likely to be adverse [ 1 ]. Overall, the benefits of fish oil supplements in reducing cardiovascular disease risk and improving overall health outcomes make them a valuable addition to a healthy lifestyle.
From the FDA Drug Label
The FDA drug label does not answer the question.
From the Research
Benefits of Fish Oil Supplements
The benefits of fish oil supplements, which are rich in omega-3 fatty acids, have been extensively studied. Some of the key benefits include:
- Reduction in the risk of sudden death caused by cardiac arrhythmias and all-cause mortality in patients with known coronary heart disease 2
- Antiarrhythmic, antithrombotic, and anti-inflammatory effects 2, 3
- Lowering of triglyceride levels, which can help reduce the risk of heart disease 3, 4, 5
- Reduction in blood pressure, although this effect is typically seen at higher dosages 2, 3
- Potential benefits in reducing the risk of coronary artery disease, myocardial infarction, heart failure, arrhythmias, and stroke 6
Mechanisms of Action
The mechanisms by which fish oil supplements exert their benefits are complex and multifaceted. Some of the possible mechanisms include:
- Prevention of arrhythmias and lowering of heart rate 3
- Decreasing platelet aggregation and lowering triglyceride levels 3, 5
- Alteration in membrane fluidity and modulation of cardiac ion channels 6
- Anti-inflammatory, anti-thrombotic, and anti-arrhythmic effects 2, 3, 6
Recommended Intake
The recommended intake of fish oil supplements varies depending on the individual's health status and goals. Some general guidelines include: