There are no official guidelines to assist in answering this question. I will search for relevant research papers instead.
From the Research
Characteristics of Fractures in Ehlers-Danlos Syndrome (EDS)
- Fractures in EDS can be pathologic, as reported in a case of a near-term neonate with arthrochalasia type EDS who presented with a pathologic skull fracture following vaginal delivery 1
- Bone fragility resulting in fractures has been reported in some types of EDS, including kyphoscoliotic, arthrochalasia, spondylodysplastic, and classic-like EDS 2
- Hypermobile and classic EDS types may have mildly decreased bone mineral density, but it is unclear if fracture rates are increased in these types 2
- Vertebral abnormalities, such as asymptomatic vertebral fractures, are common in classical and hypermobile EDS types 2, 3
- Patients with hypermobile EDS (hEDS) or hypermobility spectrum disorder (HSD) have a higher fracture prevalence and smaller bone size compared to healthy control subjects 4
- hEDS/HSD patients have a cortical bone size deficit, which may contribute to their increased fracture risk, and decreased muscle cross-sectional area, but normal bone/muscle area ratio 4
- EDS patients have reduced bone mineral density (BMD) and bone quality, as measured by trabecular bone score (TBS), and increased prevalence of vertebral fractures (VFx) 3
- Bone fractures are a common feature of EDS, with a prevalence of 19% in one study, and may be associated with other features such as osteoporosis, premature rupture of membranes, and congenital hip dislocation 5