Is it safe to take phentermine (Adipex) and Mojarrro (unknown substance) together?

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Last updated: June 30, 2025View editorial policy

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From the Guidelines

I strongly advise against taking phentermine (Adipex) and Mojarrro together without medical supervision due to the potential for serious health risks and unpredictable drug interactions. Phentermine is a prescription appetite suppressant used for weight loss that stimulates the central nervous system and increases blood pressure and heart rate, as noted in a study published in Gastroenterology 1. Mojarrro appears to be an unknown or potentially misspelled substance, which makes it impossible to evaluate potential interactions. Taking unidentified substances with prescription medications poses serious health risks including unpredictable drug interactions that could affect your heart, blood pressure, or cause other dangerous side effects. Phentermine itself requires careful medical monitoring due to its stimulant properties and cardiovascular effects, with common side effects including dry mouth, insomnia, dizziness, irritability, increased blood pressure, and elevated heart rate, as reported in a study published in Diabetes Care 1. Before combining any medications or supplements, you should consult with your healthcare provider who can properly identify all substances, evaluate your specific health situation, and provide guidance on safe medication use. This is especially important with stimulant medications like phentermine which already carry risks when used alone, such as contraindications for use in combination with monoamine oxidase inhibitors, as highlighted in a study published in Diabetes Care 1. Some key points to consider when taking phentermine include:

  • The recommended dosage is 15 to 37.5 mg orally once daily in the morning 1
  • Phentermine is contraindicated for use in combination with monoamine oxidase inhibitors 1
  • Patients with anxiety or insomnia might feel their condition is exacerbated by phentermine, and would not be ideal candidates 1
  • Phentermine requires careful medical monitoring due to its stimulant properties and cardiovascular effects 1

From the FDA Drug Label

The FDA drug label does not answer the question.

From the Research

Safety of Taking Phentermine and Mojarrro Together

There are no research papers to assist in answering this question, as there is no information available on a substance called "Mojarrro".

Available Information on Phentermine

  • Phentermine is an internationally recognised amphetamine derivative with significant appetite-suppressing properties, used for the short-term management of obesity 2.
  • The long-term use of phentermine may potentially be associated with severe cardiovascular side-effects, abuse, and dependence 2.
  • Phentermine can be used in combination with other medications, such as topiramate, for weight reduction and treatment of adverse metabolic consequences in obesity 3.
  • The combination of phentermine and topiramate has been shown to promote weight reduction and improve adiposopathic consequences leading to metabolic diseases 3.
  • Studies have investigated the cardiovascular safety of phentermine and topiramate, with results indicating no increased risk of major adverse cardiovascular events (MACE) for current users of phentermine/topiramate 4.

Potential Drug-Drug Interactions with Phentermine

  • Phentermine may interact with other medications, and the risk of potential drug-drug interactions (PDDIs) increases with long-term use 2.
  • A study found that 75% of the top 20 drugs co-prescribed with phentermine had moderate PDDIs, and 25% had severe PDDIs 2.
  • Common co-prescribed drugs with moderate PDDIs included dextromethorphan, and those with severe PDDIs included tramadol and phenylpropanolamine 2.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Potential drug-drug interactions with phentermine among long-term phentermine consumers: A retrospective analysis.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 2023

Research

Cardiovascular Safety During and After Use of Phentermine and Topiramate.

The Journal of clinical endocrinology and metabolism, 2019

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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