What is the difference in protein content between Nepro (renal-specific protein supplement) and Jevity (peptide-based nutritional supplement)?

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Last updated: July 2, 2025View editorial policy

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From the Guidelines

Nepro contains significantly more protein than Jevity, with approximately 19.1 grams of protein per 8 oz serving, compared to Jevity's 14.4 grams per 8 oz serving. This difference is intentional based on their different clinical purposes. Nepro is specifically formulated for patients with renal (kidney) disease who are on dialysis and require higher protein intake to compensate for protein losses during dialysis treatment, as recommended by guidelines such as those from the KDOQI CPG 1. Jevity, on the other hand, is a more general nutritional supplement designed for patients with normal kidney function who need standard nutritional support. Some key points to consider when choosing between Nepro and Jevity include:

  • The protein content of Nepro is tailored to meet the needs of patients on dialysis, who require a higher protein intake to maintain muscle mass and overall health.
  • The protein in Nepro is also higher quality with more essential amino acids, which is important for patients with kidney disease who are at risk of protein-energy wasting.
  • Jevity is a more general nutritional supplement that may not provide the same level of protein or essential amino acids as Nepro. It's essential to consult with a healthcare provider or dietitian before starting any nutritional supplement, especially for patients with kidney disease, to determine the best course of treatment and ensure that the patient's nutritional needs are being met 1.

From the Research

Protein Content Comparison

  • Nepro is a renal-specific protein supplement, and its protein content is not explicitly stated in the provided studies.
  • Jevity is a peptide-based nutritional supplement, but its exact protein content is also not mentioned in the studies.

Relevant Studies

  • A study from 2 compared the use of sports protein bars as an alternative to traditional renal-specific fluid supplements like Nepro in patients on hemodialysis. The study found that sports protein bars were well-accepted by patients and had advantages over fluid-based supplements in patients with fluid restrictions.
  • Another study from 3 investigated the effect of high-protein supplemental therapy on the subjective global assessment of CKD-5D patients. The study found that high-protein commercial nutritional supplements improved malnutrition status in patients, especially those with lower serum albumin levels.
  • A review from 4 discussed the importance of dietary protein intake for human health, recommending 0.8-1.6 g protein per kg body weight per day for healthy adults, depending on physical activity level.

Protein Requirements

  • The recommended dietary allowance of protein for a healthy adult with minimal physical activity is 0.8 g protein per kg body weight per day, as stated in 4.
  • For individuals with moderate to intense physical activity, higher protein intake (1.0-1.6 g per kg body weight per day) is recommended to promote skeletal-muscle protein accretion and physical strength.

Limitations

  • There are no direct comparisons between Nepro and Jevity in terms of protein content in the provided studies.
  • The studies focus on the importance of protein intake for patients with renal disease or diabetes, but do not provide specific information on the protein content of Nepro or Jevity.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Protein supplementation with sports protein bars in renal patients.

Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation, 2007

Research

Effect of high-protein supplemental therapy on subjective global assessment of CKD-5D patients.

Hemodialysis international. International Symposium on Home Hemodialysis, 2016

Research

Dietary protein intake and human health.

Food & function, 2016

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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