From the Research
Oral Nicotinamide Mononucleotide (NMN) is generally safe for human consumption at typical supplement doses, but its effectiveness remains uncertain, and more research is needed to confirm its potential benefits for human health. The most recent and highest quality study, published in 2024 1, suggests that NMN supplementation is safe and well-tolerated in healthy adults, and may have potential benefits for insulin sensitivity and cardiovascular health. However, this study had a small sample size and was only conducted for 8 weeks, so more research is needed to confirm these findings.
Some key points to consider when evaluating the safety and effectiveness of NMN supplementation include:
- The potential benefits of NMN supplementation, including improved insulin sensitivity, muscle function, and cardiovascular health, as suggested by studies such as 1 and 2
- The potential risks and side effects of NMN supplementation, including nausea, fatigue, headaches, and digestive discomfort, as reported in studies such as 3 and 2
- The need for more research to confirm the effectiveness of NMN supplementation for human health, as highlighted in reviews such as 4
- The importance of consulting with a healthcare provider before starting NMN supplementation, especially if you have existing health conditions or take medications, as recommended in studies such as 5 and 2
In terms of dosage, the most recent and highest quality study, published in 2024 1, used a dose of 250 mg per day, which is within the typical range of 250-1200 mg per day. However, more research is needed to determine the optimal dosage and duration of NMN supplementation for human health.
Overall, while NMN supplementation appears to be generally safe, more research is needed to confirm its potential benefits and optimal dosage for human health. As with any supplement, it is essential to consult with a healthcare provider before starting NMN supplementation, especially if you have existing health conditions or take medications.