What is the treatment for a second-degree sunburn?

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Last updated: July 6, 2025View editorial policy

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From the Guidelines

Treatment for a second-degree sunburn should prioritize cooling the burn, managing pain, and preventing infection, with a focus on promoting healing and minimizing complications, as recommended by the 2024 American Heart Association and American Red Cross guidelines for first aid 1. To manage a second-degree sunburn, it is essential to start by cooling the burn with a cold compress or cool bath for 10-15 minutes to reduce inflammation and pain.

  • Apply aloe vera gel or moisturizer containing aloe several times daily to soothe the skin and maintain moisture.
  • Take over-the-counter pain relievers like ibuprofen (400-600mg every 6-8 hours) or acetaminophen (500-1000mg every 6 hours) to manage pain and reduce inflammation, as these have been shown to be well-tolerated and effective in patients with second- or third-degree burns 1.
  • Keep the burned area clean by gently washing with mild soap and water, then pat dry.
  • Do not break blisters as they protect against infection; if they break naturally, clean the area and apply an antibiotic ointment like bacitracin or polysporin.
  • Cover large blisters with sterile, non-stick gauze or a nonadherent bandage to protect the wound and reduce pain, as recommended by the guidelines 1.
  • Stay hydrated by drinking plenty of water to help your skin heal.
  • Avoid sun exposure on the burned area until it's fully healed.
  • Seek medical attention if the burn covers a large area, affects the face or major joints, shows signs of infection (increased pain, redness, swelling, or pus), or doesn't improve within a few days, as these may require specialized care, including intravenous fluid resuscitation, surgery, and other treatments 1.

From the Research

Treatment for Second-Degree Sunburn

The treatment for second-degree sunburn involves various methods to promote healing, reduce pain, and prevent infection. Some of the key treatment options include:

  • Topical antimicrobial agents or advanced occlusive dressings to help reduce pain, promote healing, and prevent wound desiccation 2
  • Topical antibiotic ointment, such as triple-antibiotic ointment, which has been shown to enhance reepithelialization and reduce scar depth and contraction compared to silver-based foam dressings 2
  • Antiseptics, such as silver-based antiseptics, honey, or iodine-based antiseptics, which can help prevent infection and promote healing 3
  • Occlusive dressings, such as hydrocolloid dressings, which can provide a moist environment to promote healing and reduce pain 4, 5

Comparison of Treatment Options

Studies have compared the effectiveness of different treatment options for second-degree burns. For example:

  • A study found that topical antibiotic ointment was more effective than silver-based foam dressings in promoting reepithelialization and reducing scar depth and contraction 2
  • Another study found that honey was more effective than topical antibiotics in promoting healing and reducing infection 3
  • A study comparing hydrocolloid dressings and silver sulfadiazine cream found that hydrocolloid dressings were superior in promoting wound healing, repigmentation, and reducing pain 5

First Aid and Wound Care

First aid and wound care are crucial in the treatment of second-degree sunburn. This includes:

  • Immediate cooling of the burn with cold water to reduce edema formation and promote healing 6
  • Cleaning and dressing the wound to prevent infection and promote healing 4
  • Regular follow-up and monitoring to assess the healing progress and adjust treatment as needed 4, 5

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Topical antibiotic ointment versus silver-containing foam dressing for second-degree burns in swine.

Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2015

Research

Antiseptics for burns.

The Cochrane database of systematic reviews, 2017

Research

Outpatient burns: prevention and care.

American family physician, 2012

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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