From the FDA Drug Label
DIRECTIONS: Tap bottom of bottle 40 times before each use. 15 drops 2 times daily or 10 drops 3 times daily under tongue, hold 30 seconds and swallow. The FDA drug label does not answer the question.
From the Research
Glycyl-Histidyl-Lysine-Copper (GHK-Cu) can be absorbed sublingually, as its small molecular weight and the sublingual area's thin epithelial tissue and abundant blood vessels facilitate absorption directly into the bloodstream. The sublingual route of administration is a viable option for GHK-Cu, given its relatively small molecular weight of around 340 daltons without the copper, which makes it theoretically suitable for sublingual absorption 1.
Key Points to Consider
- The sublingual area contains thin epithelial tissue and abundant blood vessels that can facilitate absorption of small peptides directly into the bloodstream, bypassing first-pass metabolism in the liver.
- When administered sublingually, GHK-Cu would likely need to be held under the tongue for 1-2 minutes to allow for proper absorption.
- The slightly acidic environment under the tongue may help maintain the stability of the peptide.
- Many commercial GHK-Cu products are formulated for topical application rather than sublingual use, and the bioavailability via the sublingual route may differ from other administration methods.
- The copper component of GHK-Cu is essential for its biological activity, as it helps the peptide bind to cell receptors and perform its various functions including collagen stimulation, anti-inflammatory effects, and wound healing properties 2, 3, 4.
Administration and Bioavailability
Some studies suggest that the use of novel peptides can enhance the sublingual delivery of proteins, including those with larger molecular weights 1. However, it is crucial to note that the specific formulation and delivery method of GHK-Cu can impact its bioavailability and effectiveness when administered sublingually. Given the limited research specifically on the sublingual administration of GHK-Cu, further studies are needed to fully understand its absorption and bioavailability via this route.
Clinical Implications
In clinical practice, the sublingual administration of GHK-Cu may offer a convenient and non-invasive alternative to traditional routes of administration, potentially improving patient adherence and outcomes. However, healthcare providers should be aware of the potential differences in bioavailability and effectiveness compared to other administration methods and monitor patients accordingly. Overall, while the current evidence suggests that GHK-Cu can be absorbed sublingually, further research is needed to fully elucidate its pharmacokinetics and clinical implications via this route of administration.