From the FDA Drug Label
adults and children 12 years and over take 2 caplets every 6 hours while symptoms last do not take more than 6 caplets in 24 hours, unless directed by a doctor The maximum recommended dose of Tylenol for a 16-year-old is:
- 6 caplets in 24 hours Unless directed by a doctor 1
From the Research
For a 16-year-old, the maximum recommended dose of Tylenol (acetaminophen) is 650-1000 mg per dose, not to exceed 3000-3250 mg in a 24-hour period, as suggested by the FDA and supported by recent studies 2. This means the teenager can take up to 1000 mg every 6 hours as needed, but should never exceed the daily maximum of 3000-3250 mg. It's essential to check the concentration of the specific Tylenol product being used, as they come in different strengths (regular strength tablets are 325 mg each, while extra strength are 500 mg each). Weight-based dosing is sometimes used for teenagers, with 15 mg/kg per dose being a common guideline, as seen in studies such as 3. Always follow the package directions and use the measuring device provided with liquid formulations. Taking more than the recommended dose can cause serious liver damage, which may not show symptoms immediately, as highlighted in cases of massive acetaminophen ingestion 4. If the teen is taking any other medications that contain acetaminophen (many combination cold and flu products do), these amounts must be included when calculating the total daily intake to avoid exceeding the safe limit. Some studies have compared acetaminophen with other analgesics, such as ibuprofen, for pain relief in children and adolescents, but the primary concern remains the safe use of acetaminophen within the recommended dosage limits 5, 6.