From the Research
Zepbound may potentially cause depression in some patients, and it is essential to monitor mood and mental health while taking this medication, especially for those with a history of depression or other mental health conditions. The exact mechanism by which Zepbound might affect mood is not fully understood, but it may relate to its effects on various neurotransmitter systems, including serotonin and norepinephrine, which have connections to brain regions involved in mood regulation 1, 2.
Some studies have shown that selective serotonin reuptake inhibitors (SSRIs) and serotonin/norepinephrine reuptake inhibitors (SNRIs) can be effective in treating depression, but they may also have varying side-effect profiles 3, 4. For example, duloxetine, a balanced selective serotonin and norepinephrine-reuptake inhibitor, has been shown to be effective in treating major depressive disorder (MDD) and has a relatively favorable side-effect profile 4, 5.
However, it is crucial to note that the provided evidence does not directly address the relationship between Zepbound and depression. Therefore, patients taking Zepbound should be closely monitored for symptoms of depression, such as persistent sadness, loss of interest in activities, changes in sleep or appetite, or thoughts of self-harm, and contact their healthcare provider immediately if they experience any of these symptoms. The healthcare provider can help determine if the symptoms are related to the medication and adjust the treatment plan accordingly, potentially by changing the dosage, adding treatments for depression, or switching to an alternative medication for weight management.
Key considerations for patients taking Zepbound include:
- Monitoring mood and mental health closely
- Reporting any symptoms of depression to their healthcare provider immediately
- Not stopping the medication without consulting their doctor first
- Being aware of the potential for Zepbound to affect mood, although the exact mechanism is not fully understood
- Working with their healthcare provider to adjust their treatment plan if necessary to manage any symptoms of depression.