What is the treatment for left lower chest pain of musculoskeletal origin?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: July 11, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Treatment for Left Lower Chest Pain of Musculoskeletal Origin

For left lower chest pain of musculoskeletal origin, treatment should include rest, physical therapy, and short-term use of muscle relaxants such as cyclobenzaprine for up to 2-3 weeks, along with appropriate analgesics and anti-inflammatory medications. 1

Initial Assessment and Diagnosis

Before initiating treatment, it's crucial to confirm the musculoskeletal origin of chest pain and rule out serious conditions:

  • Musculoskeletal chest pain is typically characterized by:

    • Pain that can be reproduced by specific postures or movements 2
    • Tenderness to palpation of the costochondral joints 3
    • Pain that may be positional or worsened by movement 3
    • Absence of cardiac or other life-threatening symptoms
  • Key diagnostic features on physical exam:

    • Reproduction of pain with palpation of the affected area
    • Pain exacerbated by specific movements
    • Absence of concerning vital sign abnormalities (normal heart rate, blood pressure, respiratory rate)

Treatment Algorithm

First-Line Approach:

  1. Rest and Activity Modification

    • Avoid activities that exacerbate pain
    • Modify daily activities to reduce strain on chest wall muscles
  2. Physical Therapy 4

    • Manual therapy techniques
    • Transcutaneous electrical nerve stimulation (TENS)
    • Stabilization exercises for functional myofascial disorders
    • Stretching and strengthening exercises for chest wall muscles
  3. Pharmacological Management

    • Muscle Relaxants:

      • Cyclobenzaprine: 5-10 mg orally 2-3 times daily for short periods (up to 2-3 weeks) 1
      • Note: Should not be used for longer periods as effectiveness for prolonged use is not established
    • Analgesics:

      • NSAIDs (e.g., ibuprofen, naproxen) for pain and inflammation
      • Acetaminophen as an alternative for those who cannot tolerate NSAIDs

Second-Line Approach:

  1. Topical Treatments 2

    • Topical NSAIDs
    • Topical analgesics (e.g., lidocaine patches)
  2. Focal Injections 2, 5

    • Local anesthetic injections at trigger points
    • Consider corticosteroid injections for persistent inflammation

Special Considerations

  • Duration of Treatment:

    • Muscle relaxants should be limited to 2-3 weeks 1
    • Physical therapy may continue for 4-6 weeks depending on response
  • Red Flags Requiring Immediate Referral:

    • Chest pain accompanied by dyspnea, diaphoresis, or syncope
    • Pain radiating to jaw, neck, or left arm
    • New-onset pain in patients with cardiovascular risk factors
    • Pain unrelieved by musculoskeletal-targeted treatments

Follow-up and Monitoring

  • Reassess after 1-2 weeks of initial treatment
  • If no improvement, consider:
    • Reevaluation of diagnosis
    • Referral to specialist (rheumatologist, pain specialist)
    • Additional imaging studies if clinically indicated

Common Pitfalls to Avoid

  1. Failing to rule out serious cardiac or pulmonary causes before diagnosing musculoskeletal chest pain
  2. Prolonged use of muscle relaxants beyond recommended duration (2-3 weeks)
  3. Inadequate patient education about expected course and self-management strategies
  4. Overlooking psychological factors that may contribute to pain perception and chronicity

By following this structured approach to treating musculoskeletal chest pain, clinicians can provide effective symptom relief while avoiding unnecessary investigations and treatments.

References

Research

Musculoskeletal causes of chest pain.

Australian family physician, 2001

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

[Musculoskeletal-related chest pain].

Der Internist, 2017

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.