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Last updated: July 15, 2025View editorial policy

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Differential Diagnosis for Sudden Onset Lower Back Pain

Single Most Likely Diagnosis

  • Musculoskeletal Strain: This is the most common cause of sudden onset lower back pain, often resulting from lifting heavy objects, sudden movements, or minor trauma. The pain is typically localized to the lower back and may radiate to the buttocks or thighs.

Other Likely Diagnoses

  • Herniated Disc: A herniated disc can cause sudden onset lower back pain, especially if it compresses a nerve root. The pain may radiate down the leg and be accompanied by numbness, tingling, or weakness.
  • Degenerative Disc Disease: This condition can cause sudden onset lower back pain, especially if there is a sudden exacerbation of the degenerative process.
  • Spondylosis: This condition, characterized by a defect in the pars interarticularis, can cause sudden onset lower back pain, especially in young athletes.

Do Not Miss Diagnoses

  • Cauda Equina Syndrome: A serious condition that requires immediate medical attention, characterized by severe lower back pain, numbness, tingling, or weakness in the legs, and loss of bladder or bowel control.
  • Spinal Infection (e.g., Osteomyelitis, Discitis): Infections of the spine can cause sudden onset lower back pain, fever, and other systemic symptoms.
  • Spinal Fracture: A fracture of the spine can cause sudden onset lower back pain, especially if it is related to trauma or osteoporosis.
  • Abdominal Aortic Aneurysm: A ruptured abdominal aortic aneurysm can cause sudden onset lower back pain, abdominal pain, and other systemic symptoms.

Rare Diagnoses

  • Spinal Tumor: A tumor of the spine can cause sudden onset lower back pain, especially if it compresses a nerve root or causes spinal instability.
  • Paget's Disease: A rare condition characterized by abnormal bone remodeling, which can cause sudden onset lower back pain and other systemic symptoms.
  • Osteonecrosis of the Spine: A rare condition characterized by the death of bone tissue in the spine, which can cause sudden onset lower back pain and other systemic symptoms.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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