From the Guidelines
A healthy diet and topical retinoids promote skin health and reduce signs of aging.
Key Factors
- A Mediterranean diet rich in fruits, vegetables, and whole grains, as well as a vegetarian diet with low methionine content, can help reduce the risk of aging-related diseases and promote skin health 1.
- Topical retinoids, such as adapalene, tretinoin, and isotretinoin, have been shown to improve lentigines and reduce wrinkles, and are recommended for the care of patients with actinic keratosis 1.
- Antiglycative compounds, such as polyphenols found in vegetables, fruits, and red wine, can help inhibit the formation of advanced glycation end-products (AGEs), which contribute to skin aging 1.
- Functional foods and nutraceuticals containing bioactive compounds, such as olive mill wastewater and grape skin extracts, may also have anti-glycative and antioxidant effects, promoting skin health 1.
Mechanisms
- Cellular senescence plays a key role in skin aging, and senescent human melanocytes can drive skin aging via paracrine telomere dysfunction 1.
- Oxidative stress and inflammation can also contribute to skin aging, and a healthy diet and lifestyle can help mitigate these effects 1.
Recommendations
- Eat a balanced diet rich in fruits, vegetables, and whole grains to promote skin health and reduce the risk of aging-related diseases.
- Use topical retinoids as recommended by a dermatologist to improve lentigines and reduce wrinkles.
- Consider functional foods and nutraceuticals containing bioactive compounds to help inhibit AGE formation and promote skin health.
From the Research
Factors Promoting Skin Health
- Diet and nutrition play a significant role in preventing photoaging and treating common skin conditions 2, 3
- Plant-derived antioxidants, such as polyphenols, tocopherols, and carotenoids, can promote skin health and protect against harmful factors like ultraviolet radiation and free radicals 4
- Coenzyme Q10 (CoQ10) supplementation can limit seasonal deterioration of viscoelasticity and reduce visible signs of aging, including wrinkles and microrelief lines 5
Topical Treatments for Skin Aging
- Topical hyaluronic acid (HA) can improve skin quality and reduce signs of skin aging, including wrinkles and fine lines 6
- HA is a key ingredient in cosmeceuticals, providing hydration and anti-aging properties, and is well tolerated and effective in clinical studies 6
- Combining HA with other treatments, such as Botulinum toxin type A (BoNTA), can lengthen the duration of the treatment's effect in reducing wrinkles 6