Management of Tension Headache
For the treatment of tension-type headache, ibuprofen (400 mg) or acetaminophen (1000 mg) are recommended as first-line abortive therapies, while amitriptyline is suggested for prevention of chronic tension-type headache. 1
Abortive Treatment
First-line Medications
- Ibuprofen 400 mg: Recommended as a first-line treatment with favorable efficacy and side-effect profile 1, 2
- Acetaminophen 1000 mg: Equally effective for pain relief 1, 3
Important considerations:
- Lower doses of acetaminophen (500-650 mg) have not shown statistically significant improvement 1
- Both medications demonstrate statistically significant improvement in pain-free response at 2 hours 1
- Ibuprofen may have a slightly faster onset of action, with greater pain reduction at 1 hour compared to other NSAIDs 3
Alternative NSAIDs
- Naproxen 550-825 mg
- Ketoprofen 50-75 mg 4
Caution: Using pain relievers more than twice weekly increases risk of progression to chronic daily headache 5
Preventive Treatment for Chronic Tension-Type Headache
First-line Prevention
- Amitriptyline: Recommended for prevention of chronic tension-type headache 1
- Effective doses: 50-100 mg daily
- Significantly reduces monthly headache days 1
Important considerations:
- Monitor for anticholinergic adverse effects, especially in:
- Older patients
- Patients with cardiac comorbidities
- Risk of overdose 1
Treatments NOT Recommended
- Botulinum toxin injections: Evidence shows no significant improvement in chronic tension-type headache outcomes 1
- The VA/DoD Clinical Practice Guideline specifically recommends against botulinum/neurotoxin injection for chronic tension-type headache prevention 1
Non-pharmacological Approaches
Recommended Approaches
- Physical therapy: Suggested for management of tension-type headache 1
- Aerobic exercise or progressive strength training: Recommended for prevention 1
Other Approaches (Limited Evidence)
Clinical Algorithm
For acute tension headache episodes:
- Start with ibuprofen 400 mg OR acetaminophen 1000 mg
- Limit use to less than twice weekly to prevent medication overuse headache
For patients with chronic tension-type headache (≥15 headache days/month for >3 months):
- Consider amitriptyline starting at lower doses and titrating up to 50-100 mg daily
- Add physical therapy or aerobic exercise program
For inadequate response:
- Consider combination of pharmacological and non-pharmacological approaches
- Evaluate for medication overuse headache if frequent analgesic use
- Consider referral to headache specialist if poor response to treatment
Common Pitfalls to Avoid
- Using inadequate doses of acetaminophen (doses <1000 mg are less effective)
- Prescribing botulinum toxin injections for tension-type headache (not recommended)
- Failing to address medication overuse, which can perpetuate headaches
- Neglecting non-pharmacological approaches, which can be effective adjuncts
By following this evidence-based approach, most patients with tension-type headache can achieve significant improvement in symptoms and quality of life.