Treatment of Tension Headache
For acute tension headache treatment, ibuprofen (400 mg) or acetaminophen (1000 mg) are recommended as first-line options. 1, 2
Acute Treatment Options
First-line Medications:
- Ibuprofen 400 mg: Effective for short-term treatment of tension headache with significant improvement in pain-free response at 2 hours 1
- Acetaminophen 1000 mg: Equally effective for short-term treatment 1
- Important: Lower doses of acetaminophen (500-650 mg) do not show statistically significant improvement 1
Alternative Options:
- Aspirin-acetaminophen-caffeine combination: Effective for mild to moderate headaches 2
- Caution: Avoid in patients with peptic ulcer disease or bleeding disorders
Medication Administration Tips:
- Take at the onset of headache
- Take NSAIDs with food to minimize gastrointestinal side effects 2
- Treat headaches as early as possible during an attack for improved efficacy 2
Preventive Treatment for Chronic Tension Headache
For patients with frequent tension headaches requiring preventive therapy:
- Amitriptyline: Recommended for prevention of chronic tension-type headache (50-100 mg) 1
- Both doses significantly reduce monthly headache days
- Caution: Be aware of anticholinergic adverse effects, especially in older patients and those with cardiac comorbidities 1
Not Recommended:
- Botulinum toxin injections: Evidence does not support use for chronic tension-type headache prevention 1
Non-Pharmacological Approaches
These approaches can complement medication therapy:
- Maintain adequate hydration
- Regular sleep schedule
- Identify and avoid potential triggers
- Stress reduction techniques 2
- Physical therapy for tension-type headache 2
- Aerobic exercise or progressive strength training 2
Important Limitations and Precautions
- Limit medication use to prevent medication overuse headache:
Treatment Algorithm
Acute episode:
- Start with ibuprofen 400 mg OR acetaminophen 1000 mg
- If inadequate relief, consider aspirin-acetaminophen-caffeine combination
For chronic/frequent tension headaches (occurring >15 days/month for >3 months):
- Consider amitriptyline (starting at lower doses and titrating up to 50-100 mg)
- Implement non-pharmacological approaches
Follow-up:
Common Pitfalls to Avoid
- Using inadequate doses of acetaminophen (doses <1000 mg are not effective) 1
- Overuse of acute medications leading to medication overuse headache
- Failing to address lifestyle factors that may trigger headaches
- Not allowing sufficient time for preventive medications to take effect
- Ignoring comorbid conditions like anxiety and depression that may exacerbate headaches 2