Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: August 4, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Differential Diagnosis for Tongue Pain

  • Single most likely diagnosis
    • Burning mouth syndrome: This condition is characterized by a burning sensation on the tongue and other parts of the mouth without any visible signs of disease. It's a common cause of tongue pain, especially in postmenopausal women.
  • Other Likely diagnoses
    • Trauma: Accidental bites, cuts, or burns to the tongue can cause pain.
    • Oral thrush: A fungal infection that can cause white patches and pain on the tongue.
    • Geographic tongue: A condition characterized by the appearance of single or multiple, well-demarcated areas of erythema on the tongue, which can be painful.
    • Nutritional deficiencies: Deficiencies in vitamins like B12 or iron can cause tongue pain and changes in the appearance of the tongue.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Oral cancer: Although less common, tongue pain can be a symptom of oral cancer, which requires early detection for effective treatment.
    • Angina bullosa hemorrhagica: A condition characterized by the sudden onset of blood-filled blisters on the tongue or oral mucosa, which can be painful and may indicate an underlying bleeding disorder.
    • Glossopharyngeal neuralgia: A rare condition that causes sharp, stabbing pain in the tongue and throat, which can be a symptom of a more serious underlying condition.
  • Rare diagnoses
    • Pemphigus vulgaris: A rare autoimmune disease that causes blistering of the skin and mucous membranes, including the tongue.
    • Aphthous ulcers: Also known as canker sores, these are small, painful ulcers that can appear on the tongue and other parts of the mouth.
    • Erythema multiforme: A rare skin condition that can cause painful lesions on the tongue and other parts of the body.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.