From the Guidelines
To prevent wrinkles as part of an anti-aging regimen, it is essential to prioritize sun protection, use topical retinoids, and maintain a consistent skincare routine. The most critical aspect of preventing wrinkles is protecting the skin from UV damage, which can be achieved by minimizing exposure to the sun during peak hours, seeking shade, wearing protective clothing, and using a broad-spectrum sunscreen with a sun-protection factor of >15 1. Additional strategies include:
- Using topical retinoids, such as adapalene 0.3%, tretinoin 0.01% and 0.05%, and topical isotretinoin 0.01%, which have been shown to improve lentigines and reduce wrinkles 1
- Maintaining a consistent skincare routine that includes a gentle cleanser, vitamin C serum, and moisturizers, which can help to improve skin hydration and reduce inflammation 1
- Adopting healthy lifestyle habits, such as staying hydrated, consuming antioxidant-rich foods, getting 7-8 hours of sleep, and avoiding smoking and excessive alcohol, which can help to promote overall skin health. It is crucial to note that consistency is key when it comes to preventing wrinkles, and a long-term commitment to these strategies is necessary to achieve optimal results.
From the FDA Drug Label
The FDA drug label does not answer the question.
From the Research
Strategies for Preventing Wrinkles
To prevent wrinkles as part of an anti-aging regimen, several strategies can be employed:
- Using sunscreen: The right product, used in the right amount, at the right time, and in the right places can help prevent the effects of extrinsic aging 2.
- Daily broad-spectrum sunscreen photoprotection: Containing antioxidant ingredients for additional benefits against UV, IRA, and pollution-induced oxidative stress as well as anti-aging active ingredients to provide clinical benefits against skin aging signs, such as wrinkles and dark spots 3.
- Using cosmeceuticals: Topical creams containing retinol, niacinamide, resveratrol, and hexylresorcinol can provide statistically significant improvements in fine lines, radiance, and smoothness, as well as hyperpigmentation, overall skin clarity, evenness of skin tone, and wrinkles 4.
- Regular sunscreen use: Retards skin aging in healthy, middle-aged men and women, with a 24% less skin aging in the daily sunscreen group compared to the discretionary sunscreen group 5.
Additional Approaches
Other approaches to prevent skin aging and inflammaging include:
- Antioxidants: To counteract DNA damage and oxidative stress, which are critical mechanisms in skin aging 6.
- Hormone replacement therapy: And vitamins, which have been considered as treatments for skin aging 6.
- Enhancing skin penetration: Using physical, chemical, or biomaterial enhancers and carrier-based formulations to deliver anti-aging agents topically 6.