What are the common causes of skin hypersensitivity?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: March 6, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

From the Guidelines

Skin hypersensitivity is most commonly caused by allergic contact dermatitis, irritant contact dermatitis, and other inflammatory dermatoses such as eczema and seborrheic dermatitis. These conditions can be triggered by various factors, including:

  • Harsh skincare products containing fragrances and alcohol
  • Environmental factors like extreme temperatures and pollution
  • Allergic reactions to certain ingredients, such as nickel, neomycin, and fragrances
  • Medical conditions like eczema, seborrheic dermatitis, and psoriasis
  • Certain medications, such as antibiotics and antifungal agents, which can cause contact dermatitis or photosensitivity reactions 1.

The management of skin hypersensitivity involves removing the sensitizing agent, applying topical corticosteroids or other anti-inflammatory agents, and using gentle skincare products that are fragrance-free and hypoallergenic 1. Patch testing can be used to diagnose allergic contact dermatitis and identify the specific allergen responsible for the reaction 1. It is also important to note that some medications, such as amiodarone and thiazide diuretics, can cause photosensitivity reactions, and patients should be advised to take precautions to avoid excessive sun exposure 1.

In terms of prevention, using gentle skincare products, avoiding harsh chemicals and fragrances, and protecting the skin from excessive sun exposure can help to reduce the risk of skin hypersensitivity 1. Additionally, patch testing new products and consulting a dermatologist for persistent sensitivity can help to identify and manage skin hypersensitivity reactions 1. Overall, a comprehensive approach that takes into account the various causes and triggers of skin hypersensitivity is necessary to effectively manage and prevent this condition.

From the FDA Drug Label

Uses temporarily relieves itching associated with minor skin irritations, inflammation, and rashes due to: eczema psoriasis poison ivy, oak, sumac insect bites detergents jewelry cosmetics soaps seborrheic dermatitis The common causes of skin hypersensitivity include:

  • Eczema
  • Psoriasis
  • Poison ivy, oak, sumac
  • Insect bites
  • Detergents
  • Jewelry
  • Cosmetics
  • Soaps
  • Seborrheic dermatitis 2

From the Research

Common Causes of Skin Hypersensitivity

The common causes of skin hypersensitivity can be attributed to various factors, including:

  • Environmental factors such as cold, hot, dryness, pollution, wind, and chemicals 3
  • Allergic settings and intolerance to certain substances 3, 4
  • Cosmetics and skin care products, particularly those containing potentially irritant substances 3, 5
  • Occupational skin diseases or chronic exposure to irritants 5
  • Constitutional anomalies, such as a thinner stratum corneum with a reduced corneocyte area, alterations in vanilloid receptors, and changes in neuronal transmission 5, 6
  • Diminished barrier function, heightened neurosensory input, and enhanced immune responsiveness 6

Triggers of Skin Hypersensitivity

Triggers of skin hypersensitivity can include:

  • Topical medications or products 4
  • Soaps, sunscreens, and other personal care products 5
  • Certain ingredients in cosmetics and skin care products, such as preservatives and surfactants 7
  • Irritants, such as balsam of Peru 7

Factors Contributing to Skin Sensitivity

Factors contributing to skin sensitivity can be categorized into three main areas:

  • Barrier functions, including the integrity of the stratum corneum and transepidermal water loss (TEWL) 7
  • Reactivity to irritants, including the onset and intensity of skin reactions 7
  • Neuronal responses, including sensory reactions such as itching, burning, and stinging 7

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Sensitive skin: A relevant syndrome, be aware.

Journal of the European Academy of Dermatology and Venereology : JEADV, 2022

Research

Sensitive skin: an overview.

International journal of cosmetic science, 2013

Research

Sensitive skin: perceptions, evaluation, and treatment.

American journal of contact dermatitis : official journal of the American Contact Dermatitis Society, 1997

Research

Factors defining sensitive skin and its treatment.

American journal of contact dermatitis : official journal of the American Contact Dermatitis Society, 1998

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.