From the Research
Safety of Combining Benzodiazepines with Ibogaine
- There is limited research on the safety of combining benzodiazepines with ibogaine, but available studies suggest that caution is necessary due to potential adverse effects 1, 2.
- A study on the adverse events of ibogaine in humans found that seizures associated with withdrawal from benzodiazepines were a risk factor for fatalities 2.
- Another study highlighted the importance of understanding the pharmacology of ibogaine and its potential interactions with other substances, including benzodiazepines 3.
- The use of ibogaine has been associated with cardiotoxicity and neurotoxicity, which could be exacerbated by the concomitant use of benzodiazepines 4.
- A retrospective study on the treatment of drug dependence with ibogaine found no serious adverse reactions or fatalities, but the study did not specifically examine the combination of ibogaine with benzodiazepines 5.
Potential Risks and Interactions
- The combination of ibogaine with benzodiazepines may increase the risk of adverse effects, including seizures, cardiotoxicity, and neurotoxicity 1, 4, 2.
- The lack of standardized products and dosages of ibogaine, as well as the variability in individual responses to the substance, makes it difficult to predict the safety of combining it with benzodiazepines 1.
- Further research is needed to fully understand the potential risks and interactions associated with combining benzodiazepines with ibogaine 3, 1.