From the Research
Medication Treatment for Singultus
The following medications have been mentioned in the studies as potential treatments for singultus:
- Chlorpromazine, a dopamine receptor blocker, which is FDA-approved for hiccups 1, 2
- Baclofen, which has been shown to be effective in treating intractable hiccups, particularly in palliative care patients 3, 4
- Gabapentin, which may be used as an add-on to baclofen for treating intractable hiccups 3
- Serotonin (5-HT) receptor subtype ligands, such as 5-HT1A, 5-HT3, and 5-HT7 agonists, and 5-HT2C antagonists, which may enhance vagal activity and have beneficial effects on hiccup 1
Pharmacologic Approaches
Pharmacologic approaches are often the most rational therapies for treating singultus, particularly in palliative care patients 3, 5. However, it is essential to consider the underlying cause of the hiccups and direct treatment accordingly, if possible 3.
Treatment Options
Treatment options for singultus can include both pharmacologic and non-pharmacologic agents 3, 5. The choice of treatment depends on the duration and severity of the hiccups, as well as the patient's overall condition. In some cases, medication treatment may be necessary to alleviate symptoms and improve quality of life 5.