From the Guidelines

Yohimbine (Hydrochloride) is an alpha-2 adrenergic blocker that has been associated with both hypotension and hypertension.

It is a substance that may cause elevated blood pressure, and its use is generally advised against, especially in patients with uncontrolled hypertension 1.
Yohimbine is often found in herbal supplements, and its interaction with other substances like MAO inhibitors can be particularly concerning 1.
The management strategy for patients using yohimbine typically involves avoiding its use or holding it for a certain period, such as 2 weeks, before surgery or in cases of uncontrolled hypertension 1.
It's worth noting that yohimbine's effects on blood pressure can vary highly between individuals, making careful consideration and monitoring necessary 1.

In the context of perioperative management, holding yohimbine 2 weeks before surgery is recommended due to its potential to cause hypotension or hypertension 1.
For patients with hypertension, avoiding yohimbine or limiting its use is advised, given its potential to exacerbate high blood pressure 1.

From the FDA Drug Label

Yohimbine HCl Yohimbine (Hydrochloride) is Yohimbine HCl.

Yohimbine is a natural compound derived from the Pausinystalia yohimbe tree, with a rich history of use in traditional medicine 3.
It is an indole alkaloid that primarily acts as an antagonist of α2-adrenergic receptors 3, 4.
Yohimbine has been investigated for its potential therapeutic applications, including the treatment of erectile dysfunction, metabolic disorders, and as a stimulant and aphrodisiac 3, 5, 4.

Yohimbine has been shown to have a positive effect on sexual performance in animal studies, and meta-analyses of human studies have consistently shown an advantage of yohimbine over placebo in the treatment of erectile dysfunction 5.
It selectively blocks the pre and postsynaptic α2-adrenergic receptors and has a moderate affinity for α1 and α2 subtypes, and also binds to other behaviorally relevant monoaminergic receptors 4.
Yohimbine has been used to treat erectile dysfunction, with a response rate of 34% in a double-blind study, and has been shown to be active in some patients with arterial insufficiency and low serum testosterone levels 6.

Yohimbine can cause toxicological concerns, particularly at higher doses, including agitation, anxiety, hypertension, and tachycardia 7.
The potential for dose-dependent toxicity should be recognized, and yohimbine should be used with caution, especially in excess doses 7.
In a double-blind study, only few and benign side effects were recorded, making yohimbine a worth-trying medication, often as a first line of treatment 6.