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Last updated: August 24, 2025View editorial policy

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Differential Diagnosis for Burning Shoulder Pain

  • Single most likely diagnosis
    • Musculoskeletal strain or sprain: This is often the most common cause of shoulder pain, including burning sensations, due to overuse, injury, or poor posture.
  • Other Likely diagnoses
    • Tendinitis or bursitis: Inflammation of the tendons or bursae in the shoulder can cause burning pain, especially with movement.
    • Adhesive capsulitis (frozen shoulder): Characterized by stiffness and pain in the shoulder joint, which can include a burning sensation.
    • Referred pain from the neck: Cervical spine issues, such as herniated discs or cervical spondylosis, can refer pain to the shoulder, sometimes described as burning.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Myocardial infarction (heart attack): Although less common, shoulder pain can be a referred symptom of a heart attack, especially in women, and is critical not to miss.
    • Pulmonary embolism: In rare cases, a pulmonary embolism can cause referred pain to the shoulder, which would be a medical emergency.
    • Thoracic outlet syndrome: Compression of the nerves or blood vessels between the collarbone and first rib can cause burning pain in the shoulder and arm.
  • Rare diagnoses
    • Complex regional pain syndrome (CRPS): A chronic pain condition that can cause burning pain, usually after an injury or trauma.
    • Brachial neuritis: Inflammation of the nerves that control the muscles of the shoulder, which can cause severe burning pain.
    • Pancoast tumor: A type of lung cancer located at the top of the lung that can cause shoulder pain due to local invasion of the brachial plexus or ribs.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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