Isosource 1.5 vs Jevity 1.5: Nutritional Equivalence Comparison
Isosource 1.5 calorie is nutritionally equivalent to Jevity 1.5 in terms of caloric density, but they differ in their FODMAP content and fiber composition, which may impact gastrointestinal tolerance.
Nutritional Comparison
Both Isosource 1.5 and Jevity 1.5 are classified as nutritionally complete enteral formulas with similar core characteristics:
- Caloric density: Both provide 1.5 calories per mL
- Macronutrient composition: Both contain whole proteins, long-chain triglycerides, and carbohydrates predominantly as polysaccharides 1
- Completeness: Both are nutritionally complete formulas that can serve as sole sources of nutrition
- Basic features: Both are typically lactose and gluten-free 2
Key Differences
Despite their similar caloric profiles, these formulas have important differences:
FODMAP Content
- Isosource 1.5: Contains 47-71% lower FODMAP (fermentable oligosaccharides, disaccharides, monosaccharides, and polyols) content compared to other formulas including Jevity 3, 4
- Clinical impact: Lower FODMAP content in Isosource 1.5 has been associated with a five-fold reduction in diarrhea risk in enteral nutrition patients 3
Fiber Composition
- Isosource: Contains a proprietary fiber blend (IS50®) that may improve bowel function 5
- Jevity: Contains fiber but with a different composition
Clinical Considerations for Formula Selection
Gastrointestinal Tolerance
- For patients at high risk of diarrhea, Isosource 1.5 may be preferable due to its lower FODMAP content 3, 4
- High-risk patients include those with:
- Anticipated longer duration of enteral nutrition
- Expected longer hospital stay
- Concurrent antibiotic use
Flow Rate Considerations
- Flow rates between the formulas may differ slightly depending on the feeding tube size used 6
- This may be relevant for patients receiving gravity feedings
Protein Content
- While both formulas provide complete protein, specific variants like Isosource Protein Fiber have been shown to have good gastrointestinal tolerance and may help regulate intestinal transit 5
Monitoring Recommendations
Regardless of formula choice:
- Monitor for gastrointestinal symptoms, particularly diarrhea
- Assess tolerance during the first few days of administration
- Consider switching formulas if intolerance develops
Conclusion
While Isosource 1.5 and Jevity 1.5 are calorically equivalent and both nutritionally complete, Isosource 1.5 may offer advantages for patients at risk of diarrhea due to its lower FODMAP content. For standard nutritional support in low-risk patients, either formula can provide adequate nutritional support.