From the Research
The use of Epicatechin and Alpha-GPC as supplements is not supported by strong clinical evidence, and their effects on morbidity, mortality, and quality of life are unclear. When considering the use of these supplements, it is essential to weigh the potential benefits against the risks, and to prioritize a comprehensive approach to health that includes proper nutrition and exercise. The most recent and highest quality study on this topic is a 2021 systematic review that found the evidence for the efficacy and safety of dietary supplement ingredients, including Epicatechin and Alpha-GPC, to be limited and inconsistent 1. Another study published in 2021 found that Alpha-GPC supplementation may promote atherosclerosis and increase the risk of stroke, highlighting the potential risks associated with its use 2. In contrast, a 2017 study found that Epicatechin may have beneficial effects on blood lipids and hepatic steatosis, but this study was conducted in animals and its findings may not be applicable to humans 3. Overall, the evidence suggests that Epicatechin and Alpha-GPC should be used with caution, and only under the guidance of a healthcare professional. Some key points to consider when using these supplements include:
- Epicatechin may improve blood flow, exercise performance, and muscle growth, but its effects are largely based on animal studies and small human trials
- Alpha-GPC may support memory and cognitive function, but its use has been linked to an increased risk of stroke and atherosclerosis
- Both supplements are generally well-tolerated, but may cause side effects such as headaches, insomnia, and digestive issues
- The quality and safety of herbal supplements, including Epicatechin and Alpha-GPC, can vary widely depending on the manufacturer and production process 4.