What decreases the zone of stasis in a patient with an electrical injury?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: September 10, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Decreasing the Zone of Stasis in Electrical Injury

Cooling thermal burns with cold tap water (15-25°C) until pain is relieved is the most effective approach to decrease the zone of stasis in a patient with an electrical injury. 1

Understanding the Zone of Stasis

The zone of stasis is a critical area surrounding the primary burn injury that is at risk of becoming necrotic but potentially salvageable with proper intervention. In electrical burns, this zone is particularly important as the damage can extend far beyond what is initially visible.

Evidence-Based Management

Primary Intervention: Temperature Control

  • The American Heart Association recommends cooling thermal burns with cold tap water (15-25°C) until pain is relieved 1
  • This cooling process helps to:
    • Limit the progression of tissue damage
    • Reduce inflammation
    • Decrease edema formation
    • Preserve microcirculation in the zone of stasis

Why Cold Water Application Works

Cold water application works by:

  1. Reducing local tissue temperature
  2. Decreasing the metabolic demands of injured tissues
  3. Limiting the release of inflammatory mediators
  4. Preserving microvascular perfusion in the zone of stasis

Incorrect Approaches

  • Peripheral vasodilation: While this might seem logical to improve blood flow to damaged tissues, it can actually increase edema and worsen outcomes in electrical burns
  • Vasoconstriction: This would further compromise blood flow to already damaged tissues
  • Extremely cold water: Using ice or very cold water can cause additional tissue damage and is not recommended

Additional Considerations in Electrical Burn Management

  • Ensure the power source is disconnected before touching the patient 1
  • Assess for entry and exit wounds, as electrical burns can cause significant internal damage along the current pathway 1
  • Monitor for cardiac arrhythmias, which are common in electrical injuries 1
  • Maintain adequate diuresis to facilitate excretion of myoglobin and other byproducts of tissue destruction 1

Emerging Research

While cold water application remains the primary intervention, research has explored other agents that might help save the zone of stasis:

  • N-Acetylcysteine has shown promise in reducing tissue destruction in electrical burns 2
  • Melatonin has demonstrated efficacy in experimental models 3
  • Activated protein C may improve tissue perfusion and decrease necrosis 4

However, these treatments are still experimental and not part of standard guidelines for electrical burn management.

Common Pitfalls to Avoid

  • Delaying cooling treatment (should be initiated as soon as possible)
  • Using ice or extremely cold water (can cause additional tissue damage)
  • Focusing only on visible burns (electrical injuries often have significant internal damage)
  • Failing to monitor for cardiac complications
  • Underestimating the extent of tissue damage in electrical burns

References

Guideline

Electric Shock Injuries

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Research

The effect of oral N-acetylcystein on prevention of extensive tissue destruction in electrical burn injury.

Burns : journal of the International Society for Burn Injuries, 2018

Research

Saving the zone of stasis in burns with melatonin: an experimental study in rats.

Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES, 2015

Research

Saving the zone of stasis in burns with activated protein C: an experimental study in rats.

Burns : journal of the International Society for Burn Injuries, 2010

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.