From the Research
NAD+ infusions should not be administered over 30 minutes due to safety concerns, and the recommended administration rate is typically 250-500 mg NAD+ over 2-4 hours, with slower rates for first-time patients, as supported by the most recent study 1. When administering NAD+ infusions, it is crucial to prioritize patient safety and consider the potential side effects associated with rapid infusion rates.
- The recommended administration rate is typically 250-500 mg NAD+ over 2-4 hours, with slower rates for first-time patients.
- Rapid infusions can cause significant side effects including severe flushing, chest tightness, nausea, headache, and dizziness.
- These reactions occur because NAD+ triggers the release of histamine and prostaglandins when administered too quickly.
- For patient safety, start with a slow drip rate (around 100-200 mg/hour) and gradually increase as tolerated.
- Ensure proper dilution in normal saline (typically 500-1000 mL) and monitor vital signs throughout the infusion.
- If side effects occur, temporarily pause the infusion and resume at a slower rate once symptoms subside. The most recent study 1 supports the safety and effectiveness of NAD+ supplementation, but highlights the need for further research to determine the optimal method of raising NAD levels and identifying target conditions.
- The study found that NADH supplementation is safe and has a low incidence of side effects, with common side effects including muscle pain, nervous disorders, fatigue, sleep disturbance, and headaches.
- However, the study also notes that further investigations are needed to evidence the clinical benefits regarding specific diseases and doses administered. In terms of the underlying mechanisms, NAD+ plays a critical role in various biological processes, including oxidative phosphorylation and production of adenosine triphosphate, DNA repair, calcium-dependent secondary messenger and gene expression 2, 3.
- The sirtuins, a family of NAD+-dependent deacetylases, have been implicated in the regulation of various cellular processes, including metabolism, stress resistance, and aging 3.
- The identification of the contribution of the host-gut microbiota interactions to NR and NMN metabolism has added to the complexity of NAD+ metabolism 2.