From the Guidelines
Administering a Nicotinamide Adenine Dinucleotide (NAD) infusion over 30 minutes can cause discomfort, and I strongly recommend slowing down the infusion to at least 1-2 hours to minimize pain and adverse reactions. The provided evidence does not directly address the administration of NAD infusions, but it does discuss the importance of infusion rates in other contexts, such as sincalide infusion for cholecystokinin-cholescintigraphy 1 and ferumoxytol administration for iron deficiency 1. While these studies do not specifically examine NAD infusions, they highlight the significance of infusion rates in reducing adverse reactions and discomfort. For instance, the study on ferumoxytol administration notes that slowing down the infusion rate from 17 seconds to 15 minutes significantly reduced the incidence of infusion reactions 1. Similarly, when administering NAD infusions, it is crucial to prioritize the patient's comfort and safety by adjusting the infusion rate accordingly. Common side effects of rapid NAD infusions may include burning sensations, flushing, headache, and nausea, which can be mitigated by:
- Ensuring proper hydration before treatment
- Considering pre-medication with non-steroidal anti-inflammatory drugs 30 minutes before the infusion
- Asking the healthcare provider about adding lidocaine to the IV solution
- Starting with a lower dose (250-500mg) and gradually increasing over multiple sessions to build tolerance Always have NAD infusions administered by qualified healthcare professionals who can adjust the rate based on the patient's comfort level and monitor for adverse reactions.
From the Research
NAD Infusion Discomfort
- There is no direct evidence in the provided studies to suggest that administering a Nicotinamide Adenine Dinucleotide (NAD) infusion over 30 minutes causes discomfort 2, 3, 4, 5, 6.
- The studies primarily focus on the efficacy and safety of NAD+ precursors in various clinical conditions, such as chronic fatigue syndrome, older adults, Parkinson's disease, and cardiovascular disease 3, 4, 5, 6.
- Some studies report side effects associated with NAD+ supplementation, including muscle pain, nervous disorders, fatigue, sleep disturbance, and headaches 4.
- However, these side effects are not specifically related to the administration of NAD+ infusions over 30 minutes, and the studies do not provide information on the discomfort caused by such infusions.
- Further research is needed to determine the safety and efficacy of NAD+ infusions and to assess potential discomfort or side effects associated with their administration.