From the Research
Progesterone can improve sleep quality in certain individuals, particularly those with hormonal imbalances, as evidenced by its natural sedative effects and ability to enhance GABA activity in the brain. The most recent and highest quality study, published in 2018 1, found that oral micronized progesterone (300mg at bedtime) effectively treated hot flushes and night sweats, improved sleep, and was likely safe in menopausal women. This study suggests that progesterone may be a beneficial treatment option for sleep disturbances in menopausal women.
Key points to consider when using progesterone for sleep include:
- Typical prescription doses range from 100-200mg taken orally before bedtime
- Micronized progesterone (such as Prometrium) is generally preferred for sleep benefits due to its better brain penetration
- Natural progesterone creams (20-40mg) are also available over-the-counter but may be less effective
- Side effects can include morning grogginess, dizziness, or headaches
- Progesterone therapy should be discussed with a healthcare provider before starting, especially for those with certain medical conditions like hormone-sensitive cancers, liver disease, or history of blood clots
It's essential to note that progesterone is not typically recommended as a first-line sleep aid for those without hormonal imbalances, and its effects vary significantly between individuals. However, for those with sleep issues related to hormonal imbalances, progesterone supplementation may be beneficial, as supported by the study published in 2011 2, which found that progesterone prevented sleep disturbances and modulated GH, TSH, and melatonin secretion in postmenopausal women.