What are the steps and considerations for placing a central line?

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Last updated: September 13, 2025View editorial policy

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Central Line Placement: Procedure, Challenges, and Best Practices

When placing a central venous catheter, use real-time ultrasound guidance with strict aseptic technique including maximal barrier precautions to minimize complications and infection risk. 1

Pre-Procedure Preparation

Site Selection

  • Preferred insertion sites (in order of preference):
    • Internal jugular vein (lowest infection risk for upper body sites)
    • Subclavian vein (low infection risk but higher mechanical complications)
    • Avoid femoral site when possible due to higher infection risk 1
    • Right-sided placement generally preferred to reduce risk of malposition 2

Equipment Preparation

  • Ensure standardized equipment set is available 1
  • Select appropriate catheter:
    • Choose smallest size catheter appropriate for clinical situation
    • Select catheter with minimum number of lumens needed 1
    • Consider antimicrobial-coated catheters for high-risk patients 1

Patient Preparation

  • Position patient in Trendelenburg position for neck/chest access when clinically appropriate 1
  • For femoral access, consider head-up (reverse Trendelenburg) position 1

Infection Prevention Measures

Maximal Sterile Barrier Precautions

  • Hand hygiene before procedure (alcohol-based product or soap and water) 1
  • Wear sterile cap, mask covering mouth and nose, sterile gown, and sterile gloves 1
  • Use large sterile full-body drape 1, 3
  • Cover ultrasound probe and cable with sterile cover 1

Skin Preparation

  • Use alcoholic chlorhexidine solution (minimum 2% CHG) for skin antisepsis 1
  • Allow antiseptic solution to completely dry before puncture 1
  • If chlorhexidine contraindicated, use povidone-iodine or alcohol 1

Ultrasound-Guided Insertion Technique

Step 1: Identify Anatomy

  • Use ultrasound to identify vein, artery, and surrounding structures 1, 2
  • Examine in both short-axis (transverse) and long-axis (longitudinal) views 1
  • Check for anatomic variations 1

Step 2: Confirm Vein Patency

  • Use compression ultrasound to exclude venous thrombosis 1
  • Use color Doppler to differentiate between venous and arterial vessels 1, 2

Step 3: Real-Time Ultrasound Guidance

  • Align insertion site, needle, and ultrasound screen in line of sight 1
  • Visualize needle tip throughout procedure to avoid posterior wall puncture 2
  • Base number of insertion attempts on clinical judgment 1

Step 4: Confirm Wire Position

  • Verify guidewire is in vein using both short-axis and long-axis views before dilator insertion 1, 2

Step 5: Catheter Placement

  • Thread catheter over guidewire using Seldinger technique 1
  • For subclavian approach, use thin-wall needle technique 1
  • For jugular/femoral approach, select technique based on operator experience 1

Step 6: Confirm Catheter Position

  • Verify catheter is in vein using ultrasound in both views 1, 2
  • Confirm tip position with chest X-ray (ideal position: lower third of SVC) 2

Post-Procedure Care

Dressing and Securement

  • Apply sterile, transparent dressing over insertion site 1
  • Replace dressing no more than once weekly unless soiled or loose 1
  • Use sutureless securement device 1

Maintenance

  • Clean catheter access ports with appropriate antiseptic before each access 1
  • Cap stopcocks or access ports when not in use 1
  • Replace administration sets at least every 7 days (24 hours after blood products) 1
  • Perform daily assessment of catheter necessity 1

Common Challenges and Complications

During Insertion

  • Arterial puncture: Use ultrasound to confirm vessel identity before puncture 2
  • Difficult cannulation: Consider alternative sites if multiple attempts unsuccessful 1
  • Anatomical variations: Pre-procedure ultrasound mapping helps identify variations 1

Post-Insertion Complications

  • Pneumothorax: More common with subclavian approach; confirm with chest X-ray 2, 4
  • Malposition: Verify tip position with imaging 2
  • Infection: Monitor for signs of infection; remove catheter if CLABSI suspected 1
  • Thrombosis: More common with femoral placement and larger catheters 4

Quality Improvement Strategies

  • Use a checklist or protocol for placement and maintenance 1, 5
  • Have an assistant during placement 1
  • Implement bundle approach for insertion and maintenance 1, 5
  • Conduct surveillance of central line-associated bloodstream infections 1
  • Provide education and competency assessment for all healthcare providers involved 1

Strict adherence to all components of central line bundles significantly reduces infection rates, with studies showing up to 66% decrease in central line-associated bloodstream infections when all elements are followed 1, 5.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Guideline

Central Venous Catheter Placement Guideline

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Research

Central line complications.

International journal of critical illness and injury science, 2015

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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