What are the key components and best practices for central line placement?

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Last updated: October 7, 2025View editorial policy

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Central Line Placement: Best Practices and Technique

Real-time ultrasound guidance should be used for central venous catheter placement, particularly for the internal jugular vein, to reduce complications and increase safety. 1

Preparation and Equipment

  • Gather necessary equipment including sterile drapes, personal protective equipment (hat, mask, sterile gloves, sterile gown), ultrasound machine with high-frequency linear probe, sterile ultrasound probe cover, sterile gel, and central venous catheter kit 2
  • Use a standardized equipment set and follow a checklist or protocol for central line placement 1
  • Position the patient appropriately:
    • Trendelenburg position for internal jugular or subclavian approach to increase venous filling 1
    • Reverse Trendelenburg position for femoral vein approach 1
    • For internal jugular vein access, minimize head rotation to reduce arterial-venous overlap 1

Systematic Six-Step Approach to Central Line Placement

Step 1: Identify Anatomy and Localize the Vein

  • Use ultrasound to identify the target vein, adjacent artery, and surrounding anatomic structures 1
  • Check for anatomic variations, which occur in a significant proportion of patients 1, 2
  • Use both short-axis (transverse) and long-axis (longitudinal) views of the vessels 1
  • Perform this step before prepping and draping the puncture site 1

Step 2: Confirm Patency of the Vein

  • Use compression ultrasound to exclude venous thrombosis 1
  • Apply color Doppler imaging and Doppler flow measurements to confirm vein patency and quantify blood flow 1, 2

Step 3: Use Real-time Ultrasound Guidance for Vein Puncture

  • Implement strict aseptic technique including:
    • Large sterile drape over puncture site
    • Hat, mask, sterile gloves, sterile body gown
    • Sterile ultrasound probe cover and sterile gel 1
  • Use chlorhexidine-containing solution with alcohol for skin preparation 1
  • Position yourself to have the insertion site, needle, and ultrasound screen in your line of sight 1
  • Use the "single-operator technique" - hold the ultrasound probe with non-dominant hand while advancing the needle with dominant hand 1
  • Choose either short-axis/out-of-plane or long-axis/in-plane approach based on experience and clinical situation 1
  • Constantly identify the needle tip during approach and puncture 1

Step 4: Confirm Needle Position in the Vein

  • Verify that the needle tip is placed centrally in the vein before advancing the guidewire 1
  • Do not rely solely on blood color or absence of pulsatile flow for confirming venous placement 1
  • Use ultrasound, manometry, or pressure-waveform analysis to confirm venous access 1

Step 5: Confirm Wire Position in the Vein

  • Confirm correct guidewire position in both short-axis and long-axis ultrasound views 1
  • For thin-wall needle technique, always confirm venous residence of the wire after threading 1
  • For catheter-over-needle technique, wire confirmation may not be needed if:
    • Catheter enters vein easily AND
    • Manometry/pressure-waveform confirms venous location AND
    • Wire passes through catheter without difficulty 1

Step 6: Confirm Catheter Position in the Vein

  • Verify correct catheter position in the vein using ultrasound in both short-axis and long-axis views 1
  • Confirm final catheter tip position at the cavoatrial junction as soon as clinically appropriate, typically via chest radiograph 1, 2
  • Verify that the guidewire has been completely removed from the patient by confirming its presence in the procedural field 1

Site Selection Considerations

  • Base catheter insertion site on clinical need, practitioner experience, and skill 1
  • Select an upper body insertion site (internal jugular or subclavian) when possible to minimize thrombotic complications compared to femoral site 1
  • Choose a site that is not contaminated or potentially contaminated (avoid burned/infected skin, inguinal area, areas adjacent to tracheostomy or open surgical wounds) 1
  • Select the smallest catheter size appropriate for the clinical situation 1

Technique-Specific Recommendations

  • For subclavian approach, use a thin-wall needle (Seldinger) technique rather than catheter-over-needle (modified Seldinger) technique 1
  • For internal jugular or femoral approach, select either thin-wall needle or catheter-over-needle technique based on clinical situation and operator experience 1
  • Limit the number of insertion attempts based on clinical judgment 1

Management of Complications

  • If unintended arterial cannulation with a large-bore catheter occurs, leave the catheter in place and consult a vascular surgeon or interventional radiologist immediately 1
  • If the complete guidewire cannot be located in the procedural field, order chest radiography to check for wire retention in the vascular system 1
  • Monitor for common complications including pneumothorax (0.4% prevalence with subclavian approach) and accidental arterial puncture (1.3% with subclavian approach) 3
  • Central line-associated bloodstream infections can be minimized through proper maintenance and care after placement 4

Common Pitfalls and How to Avoid Them

  • Relying solely on anatomic landmarks without ultrasound guidance increases complication risk, especially with anatomic variations 1
  • Failure to confirm venous placement can lead to arterial dilation/cannulation - always verify with ultrasound, manometry, or pressure waveform 1
  • Excessive head rotation during internal jugular vein access increases overlap with carotid artery - minimize rotation 1
  • Inadequate aseptic technique increases infection risk - always use maximal barrier precautions 1
  • Retained guidewires are preventable - always verify complete removal of wire 1
  • Catheter tip malposition can cause complications - confirm final position with imaging 1, 2

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Guideline

Central Venous Pressure Monitoring Setup and Guidance

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Research

Central Line Care and Management: Adopting Evidence-Based Nursing Interventions.

Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses, 2021

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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