From the Guidelines
To enhance NAD+ infusion, the most effective supplements to take alongside treatment are Nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN), which can be taken at doses of 250-500mg daily for NR or 250-1000mg daily for NMN, as supported by the most recent evidence 1.
Key Supplements for NAD+ Infusion
- Nicotinamide riboside (NR): 250-500mg daily
- Nicotinamide mononucleotide (NMN): 250-1000mg daily
- Resveratrol: 500-1000mg daily, which works synergistically with NAD+ precursors by activating sirtuins, the proteins that utilize NAD+, as noted in the context of nutrient conversion and energy production 1
- Quercetin: 500-1000mg daily, inhibiting CD38, an enzyme that degrades NAD+, thereby preserving levels
- Apigenin: 50-100mg daily, similarly inhibiting CD38
- Trimethylglycine (TMG/betaine): 500-1000mg daily, helping prevent methyl group depletion that can occur with high-dose niacin derivatives
- Vitamin B complex, particularly B1, B2, and B3: supports NAD+ metabolism pathways, with niacin being a crucial component for NAD+ production 1
- Zinc: 15-30mg daily, acting as a cofactor for NAD+-dependent enzymes
- Magnesium: 300-400mg daily, also acting as a cofactor for NAD+-dependent enzymes
Rationale for Supplement Selection
The selection of these supplements is based on their ability to either provide direct NAD+ precursors, protect existing NAD+ from degradation, or enhance the activity of NAD+-dependent pathways in the body. The combination of these supplements, taken consistently for at least 2-4 weeks before NAD+ infusion and continued during treatment, is expected to yield optimal results, considering the role of niacin and its derivatives in energy production, DNA repair, and antioxidant effects 1.
From the FDA Drug Label
The FDA drug label does not answer the question.
From the Research
Supplements to Enhance NAD+ Infusion
To enhance Nicotinamide adenine dinucleotide (NAD+) infusion, several supplements can be considered:
- Nicotinamide riboside (NR) 2: NR has been shown to increase NAD+ content in the body and has potential health benefits for treating various metabolic, neurodegenerative, and cardiovascular disorders.
- Nicotinamide mononucleotide (NMN) 3: NMN is another NAD+ precursor that has been found to increase hepatic NAD+ levels, prevent hepatic lipid accumulation, and improve hepatic mitochondrial function in pre-clinical models of non-alcoholic fatty liver disease (NAFLD).
- Vitamin B3 4: Vitamin B3 supplementation can manipulate NAD+ bioavailability, and its derived anabolites and catabolites contribute to essential bioenergetics, anabolic, and catabolic pathways.
- NADH 5: NADH supplementation has been shown to be safe and well-tolerated, with observed clinical results including decreased anxiety, maximum heart rate, and increased muscle insulin sensitivity.
Potential Benefits and Considerations
The use of these supplements may have various benefits, including:
- Improved energy metabolism and redox function
- Enhanced mitochondrial function and biogenesis
- Increased insulin sensitivity and glucose metabolism
- Neuroprotective effects and potential therapeutic applications for neurodegenerative diseases However, it is essential to note that while these supplements show promise, further research is needed to fully understand their effects and optimal dosing regimens 5, 6, 2, 3.