Safety of 100,000 IU Vitamin D3 Injection
A 100,000 IU injection of Vitamin D3 (Cholecalciferol) is generally safe when administered appropriately for vitamin D deficiency, but should be used with caution and under medical supervision. 1, 2
Dosing Context and Safety Profile
- High-dose vitamin D3 injections (100,000 IU) are used clinically for rapid correction of vitamin D deficiency
- According to clinical guidelines, much higher doses (500,000 IU) can be safely administered as a single dose in critically ill patients with documented deficiency 3
- Research shows that intramuscular injection of 600,000 IU vitamin D3 effectively increases serum 25(OH)D levels without causing metabolic abnormalities 4
Safety Considerations
Potential Risks
- Temporary increases in serum calcium levels may occur but typically remain within normal clinical ranges 4
- Hypercalciuria occurs more frequently with higher doses (31% with 10,000 IU daily) 5
- Hypercalcemia is rare with appropriate dosing but more common with higher doses 5
Contraindications
- Not recommended for:
- Children
- Pregnant or lactating women
- Individuals with liver disease
- Patients with hypercalcemia
- Patients with malabsorption syndrome
- Patients with abnormal sensitivity to vitamin D
- Patients with hypervitaminosis D 2
Cautions
- Patients taking thiazide diuretics may be at greater risk of toxicity 2
- Monitoring is essential, especially for high-dose administration
Monitoring Recommendations
- Serum calcium and phosphorus levels should be monitored at least every 3 months during recovery from high-dose vitamin D administration 1
- Vitamin D levels should be checked after 3 months to ensure target levels have been reached 1
- Optimal serum levels of 25(OH)D are considered to be between 30-80 ng/mL 1
Clinical Context for High-Dose Administration
- For severe vitamin D deficiency (<5 ng/mL), individualized treatment under close monitoring is recommended 1
- For moderate deficiency (5-15 ng/mL), guidelines recommend 50,000 IU weekly for 4-8 weeks 1
- In critically ill patients with measured low plasma levels (<12.5 ng/ml or 50 nmol/l), a single high dose of vitamin D3 (500,000 IU) can be administered within a week after admission 3
Long-term Safety Data
- Research has shown that even daily doses of vitamin D3 ranging from 10,000 to 60,000 IU have been safely tolerated for extended periods (2-6 years) without adverse events 6
- A randomized controlled trial demonstrated that daily doses up to 10,000 IU had a safety profile similar to 400 IU daily 5
In conclusion, while a 100,000 IU injection of Vitamin D3 is generally safe when administered appropriately for vitamin D deficiency, it should be used with proper medical supervision, appropriate patient selection, and follow-up monitoring to ensure safety and efficacy.