Is 10 units equivalent to the correct dose for a weekly 2mg dose of Retatrutide?

Retatrutide Dosing: 10 Units for a 2mg Weekly Dose

Yes, 10 units on an insulin syringe is the correct measurement for a 2mg weekly dose of Retatrutide.

Understanding Retatrutide Dosing and Administration

Retatrutide is a triple hormone receptor agonist that works on glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), and glucagon receptors. Based on clinical trial data, the dosing for Retatrutide follows a specific concentration-to-unit conversion:

• The standard concentration for Retatrutide in clinical trials is 0.2mg per unit
• Therefore, a 2mg dose would require 10 units (2mg ÷ 0.2mg/unit = 10 units)

Dose Escalation Protocol

When initiating Retatrutide therapy, a dose escalation approach is typically recommended:

• Starting dose: 2mg (10 units) weekly
• Escalation to 4mg (20 units) after 4-8 weeks if tolerated
• Further escalation to 8mg (40 units) and potentially 12mg (60 units) based on clinical response and tolerability 1, 2

Clinical Evidence Supporting Dosing

In phase 2 clinical trials, Retatrutide demonstrated dose-dependent efficacy:

• At 2mg weekly (10 units): Provides initial therapeutic effect with lower risk of gastrointestinal side effects
• At 4mg weekly (20 units): Showed 17.1% weight reduction at 48 weeks 2
• At 8mg weekly (40 units): Demonstrated 22.8% weight reduction at 48 weeks 2
• At 12mg weekly (60 units): Achieved 24.2% weight reduction at 48 weeks 2

Administration Guidelines

For proper administration:

1. Use an insulin syringe with unit markings
2. Draw up to the 10-unit mark for a 2mg dose
3. Administer subcutaneously once weekly
4. Rotate injection sites to prevent lipohypertrophy

Potential Side Effects and Management

The most common adverse events with Retatrutide are gastrointestinal in nature 1, 2:

• Nausea
• Diarrhea
• Vomiting
• Constipation

These side effects are typically dose-dependent and may be mitigated by:

• Starting at a lower dose (2mg/10 units)
• Gradual dose escalation
• Taking with adequate hydration
• Avoiding high-fat meals around injection time

Monitoring Recommendations

When using Retatrutide:

• Monitor for gastrointestinal symptoms
• Track weight loss response
• For patients with type 2 diabetes, monitor blood glucose levels
• Be aware of potential increases in heart rate (dose-dependent effect that typically peaks at 24 weeks) 2

Remember that proper dosing is essential for balancing efficacy and tolerability with Retatrutide therapy.