What volume should be drawn from a reconstituted 60mg Retatrutide vial (with 3mL bacteriostatic water) for a 2mg dose?

Calculating Retatrutide Dosage from a Reconstituted Vial

To administer a 2mg dose of Retatrutide from a 60mg vial reconstituted with 3mL bacteriostatic water, you should draw up 0.1mL (10 units on a 1mL insulin syringe).

Dosage Calculation

The calculation for determining the correct volume is straightforward:

1. Concentration calculation:

   • Total drug amount: 60mg
   • Total volume after reconstitution: 3mL
   • Concentration: 60mg ÷ 3mL = 20mg/mL

2. Volume needed for 2mg dose:

   • Dose needed: 2mg
   • Volume = Dose ÷ Concentration
   • Volume = 2mg ÷ 20mg/mL = 0.1mL

3. Units on a 1mL syringe:

   • 1mL syringe has 100 units
   • 0.1mL = 10 units

Administration Guidelines

• Use a 1mL insulin syringe with 100-unit markings for precise measurement
• Ensure the reconstituted solution is clear and free of particles before drawing up
• Draw exactly 10 units (0.1mL) for a 2mg dose
• Administer subcutaneously as directed by your healthcare provider

Important Considerations

• Retatrutide is a triple-hormone-receptor agonist (GIP, GLP-1, and glucagon) used for obesity and type 2 diabetes 1, 2
• The medication should be stored according to manufacturer recommendations after reconstitution
• Most common adverse events are gastrointestinal in nature (nausea, diarrhea, vomiting) 1
• Proper dosing is critical for both efficacy and minimizing side effects

Common Pitfalls to Avoid

• Using the wrong size syringe could lead to inaccurate dosing
• Failing to mix the reconstituted solution properly before drawing up
• Miscalculating the concentration after reconstitution
• Drawing up too much or too little medication

Remember that the concentration of your reconstituted solution is 20mg/mL, so each 0.1mL contains 2mg of Retatrutide.