Treatment of Tension Headache
For most patients with tension headache, over-the-counter NSAIDs such as ibuprofen (400-600mg) or naproxen sodium (500-550mg) are the first-line treatment, with non-pharmacological approaches including stress management and lifestyle modifications as important adjuncts. 1, 2
Pharmacological Management
Acute Treatment
First-line therapy:
Second-line therapy:
NOT recommended:
Preventive Treatment
For chronic tension-type headache (≥15 days/month for at least 6 months):
First-line preventive therapy:
Second-line preventive options:
- Mirtazapine
- Venlafaxine 2
Non-Pharmacological Approaches
Evidence-based options:
Additional options with limited evidence:
Lifestyle Modifications
- Identify and avoid trigger factors 6, 1
- Maintain regular sleep schedule 1
- Ensure adequate hydration 6, 1
- Limit caffeine intake 6
- Regular meals 6
- Stress management techniques 6, 1
Treatment Algorithm
For episodic tension headache (< 15 days/month):
- Start with NSAIDs or simple analgesics
- Add non-pharmacological approaches
- Limit medication use to avoid medication overuse headache
For chronic tension headache (≥ 15 days/month):
- Consider prophylactic treatment with amitriptyline
- Continue appropriate acute treatment for breakthrough headaches
- Implement comprehensive non-pharmacological approaches
Important Cautions
- Avoid using analgesics more than twice weekly to prevent medication overuse headache 3
- Monitor for side effects of amitriptyline including drowsiness, weight gain, and anticholinergic symptoms 6
- NSAIDs carry cardiovascular and gastrointestinal risks, particularly with prolonged use 8
- Combined therapy (medication plus stress management) is more effective than either approach alone, with 64% of patients achieving significant reduction in headache severity compared to 38% with medication alone 4
Special Considerations
- For patients with mixed tension and migraine headaches, amitriptyline may be particularly effective 6
- Patients with chronic tension headache often experience moderate to high severity pain (mean score 6.62/10), with headaches occurring approximately 5 days per week and lasting about 8.7 hours per day 9
- Married patients, those with illness duration less than two years, and those treated with only analgesics tend to report higher headache severity 9
The combination of appropriate pharmacological treatment and non-pharmacological approaches offers the best chance for successful management of tension headaches.