Is 4ml of bacteriostatic water (bacteriostatic water for injection) suitable for reconstituting a 60mg powder vial of Retatrutide (generic name)?

Reconstitution of Retatrutide 60mg Powder Vial

4ml of bacteriostatic water is appropriate for reconstituting a 60mg powder vial of Retatrutide.

Rationale for Reconstitution Volume

When reconstituting injectable medications like Retatrutide, the appropriate volume of diluent is critical for ensuring:

1. Complete dissolution of the active ingredient
2. Appropriate concentration for accurate dosing
3. Proper stability of the reconstituted solution

For a 60mg powder vial of Retatrutide, 4ml of bacteriostatic water provides an appropriate concentration that balances solubility and dosing precision. This results in a concentration of 15mg/ml, which allows for manageable dose measurements.

Reconstitution Procedure

For optimal reconstitution of Retatrutide:

• Use sterile technique throughout the process
• Allow the vial to reach room temperature before reconstitution
• Inject 4ml of bacteriostatic water slowly against the glass wall of the vial
• Gently swirl (do not shake) the vial to dissolve the powder completely
• Inspect the solution to ensure it is clear and free of particulate matter

Bacteriostatic Water Considerations

Bacteriostatic water for injection is the appropriate diluent for Retatrutide as it:

• Contains a preservative (typically 0.9% benzyl alcohol) that inhibits bacterial growth
• Allows for multiple withdrawals from the same vial over time
• Has a pH range of 4.5-7.0, which is compatible with most peptide medications 1

Storage After Reconstitution

After reconstituting Retatrutide with bacteriostatic water:

• Store the reconstituted solution in the refrigerator (2-8°C)
• Protect from light
• Use within the stability period indicated by the manufacturer (typically 14-28 days)
• Discard if the solution becomes cloudy or contains particles

Clinical Considerations

Retatrutide is a triple-hormone-receptor agonist that has shown significant efficacy in clinical trials for obesity and type 2 diabetes:

• In phase 2 trials, Retatrutide demonstrated dose-dependent weight reduction of up to 24.2% at 48 weeks 2
• Higher doses (8mg and 12mg) achieved weight reduction of 15% or more in 75-83% of participants 2
• The medication also showed significant improvements in glycemic control in patients with type 2 diabetes 3

Potential Pitfalls to Avoid

1. Incorrect reconstitution volume: Using too little diluent may result in incomplete dissolution; too much may lead to inaccurate dosing
2. Vigorous shaking: Can cause foaming and protein denaturation
3. Using non-bacteriostatic water: May reduce stability and increase contamination risk if multiple doses are withdrawn
4. Failure to use sterile technique: Increases risk of contamination

By following these guidelines, you can ensure proper reconstitution of Retatrutide 60mg powder vial with 4ml of bacteriostatic water for optimal therapeutic outcomes.