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Differential Diagnosis for Peeling Skin on Feet

Single Most Likely Diagnosis

  • Dry Skin (Xerosis): This is the most common cause of peeling skin on the feet, often due to environmental factors, lack of moisture, or excessive washing.

Other Likely Diagnoses

  • Athlete's Foot (Tinea Pedis): A fungal infection that can cause peeling skin, especially between the toes, due to moisture and warmth.
  • Eczema (Atopic Dermatitis): A chronic skin condition characterized by itchy, inflamed skin that can peel, especially if not properly managed.
  • Psoriasis: An autoimmune condition that can cause thick, scaly, peeling skin patches on various parts of the body, including the feet.

Do Not Miss Diagnoses

  • Staphylococcal Scalded Skin Syndrome (SSSS): A serious condition caused by staphylococcal toxins that can lead to widespread skin peeling, more common in children but can occur in adults with significant morbidity.
  • Toxic Epidermal Necrolysis (TEN): A life-threatening skin condition usually triggered by medications, leading to widespread skin peeling and detachment.
  • Pemphigus: A group of autoimmune diseases that can cause blistering and peeling of the skin, which can be life-threatening if not treated promptly.

Rare Diagnoses

  • Keratolysis Exfoliativa: A rare condition characterized by recurrent episodes of peeling skin on the palms and soles, often without an identifiable cause.
  • Pityriasis Rubra Pilaris (PRP): A rare skin disorder that can cause constant scaling, peeling, and thickening of the skin, including on the feet.
  • Acral Peeling Skin Syndrome: A rare genetic disorder that leads to recurrent peeling of the skin on the hands and feet, starting in infancy or early childhood.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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