What is the recommended protocol for PRP (Platelet-Rich Plasma) scalp treatment for hair loss?

Recommended Protocol for PRP Scalp Treatment for Hair Loss

The recommended protocol for PRP (Platelet-Rich Plasma) scalp treatment for hair loss is a series of 3-5 sessions at monthly intervals, using manually prepared double-spin PRP injected at a dose of 5-7 mL (0.05-0.1 mL/cm²) per session. 1

PRP Preparation Method

• Double-spin method is preferred over single-spin method for PRP preparation 1, 2
  • Studies show significantly higher terminal hair density with double-spin PRP compared to single-spin PRP 2
  • Recommended platelet concentration: 1-1.5 million platelets per μL 1
• Manual preparation is recommended over automated systems 1
• Activation of PRP is not required for androgenetic alopecia treatment 1
  • Research shows no significant difference in VEGF concentration with calcium activation 2

Treatment Schedule and Administration

• Initial treatment course:
  • 3-5 sessions at 1-month intervals 1, 3
  • Most clinical studies use 3 sessions as standard protocol 4, 5
• Injection technique:
  • Intradermal injections directly into the scalp 1, 2
  • Recommended dose: 5-7 mL total PRP per session
  • Concentration: 0.05-0.1 mL/cm² of affected area 1
• Pain management:
  • Topical pharmaceutical-grade numbing cream is highly recommended 1

Expected Outcomes and Follow-up

• Clinical improvements typically include:

  • Increased hair density (reported in 46-64% of patients) 4
  • Improved hair thickness (38-45% of patients) 4
  • Enhanced hair quality (46-54% of patients) 4
  • New hair growth (57-68% of patients) 4
  • Reduced hair loss (20-48% of patients) 4

• Timeline for results:

  • Initial improvements may be visible at 2 months 5
  • Optimal results typically seen after completing the full treatment course
  • Follow-up evaluation recommended at 1 month after the last treatment 4
  • Long-term assessment at 6-12 months to evaluate maintenance 5

• Patient satisfaction:

  • Average satisfaction score of 7.29/10 reported in clinical studies 4
  • High likelihood of patients recommending treatment to others (8/10) 4

Combination Therapy Considerations

• PRP is most effective when combined with conventional treatments:
  • Consider combining with topical minoxidil for enhanced results 3
  • PRP shows particular benefit for poor responders to conventional therapy 3
  • Can be used alongside oral finasteride in male patients 3

Common Pitfalls and Caveats

1. Standardization issues:

   • Lack of standardized protocols has led to variable results across studies 1
   • Ensure consistent preparation method and treatment intervals

2. Patient selection:

   • Best results typically seen in early to moderate androgenetic alopecia 1
   • Less effective for advanced hair loss

3. Maintenance treatment:

   • Relapse may occur 12-16 months after treatment completion 5
   • Consider maintenance sessions every 6-12 months

4. Safety considerations:

   • While generally safe, proper sterile technique is essential
   • No significant negative effects reported in major studies 4, 5

5. Realistic expectations:

   • Patients should understand that complete hair restoration is unlikely 3
   • Maintenance of existing hair and modest regrowth is considered successful 3

PRP represents a safe and effective treatment option for androgenetic alopecia with high patient satisfaction rates and minimal side effects when properly administered according to the recommended protocol.